Financial Release
"
First-Quarter Results
- Worldwide net revenues were
$5.96 billion in the first quarter, up 18.2 percent. On an operational basis, net revenues increased 22.4 percent, excluding a 4.2 percent unfavorable impact from foreign exchange rate fluctuations. - Global HUMIRA sales increased 19.2 percent on an operational basis, excluding the impact of foreign exchange. Reported HUMIRA sales increased 14.9 percent. Strong U.S. HUMIRA growth was driven by continued momentum across all three major market categories - rheumatology, dermatology and gastroenterology. International HUMIRA sales growth was also strong in the first quarter and ahead of our guidance.
- First quarter global IMBRUVICA net revenue was
$381 million , with U.S. sales of$325 million and international profit sharing of$56 million for the quarter. - Total company revenue growth was also driven by
$414 million in global VIEKIRA sales in the quarter, as well as strong operational growth from Duodopa and Creon. - Adjusted gross margin ratio in the first quarter was 81.3 percent, excluding intangible asset amortization and other specified items. On a GAAP basis, the gross margin ratio was 77.0 percent.
- Adjusted selling, general and administrative (SG&A) expense was 22.6 percent of net revenues in the first quarter. On a GAAP basis, SG&A was 22.7 percent of net revenues.
- Adjusted research and development (R&D) expense was 15.6 percent of net revenues in the quarter, reflecting funding actions supporting all stages of our pipeline. On a GAAP basis, R&D was 15.9 percent.
- Adjusted operating margin in the first quarter was 43.1 percent, compared to 40.1 percent in first-quarter 2015. On a GAAP basis, the operating margin was 38.2 percent.
- Net interest expense was
$200 million . The adjusted tax rate in the quarter was 20.7 percent and 23.7 percent on a GAAP basis. - Adjusted diluted earnings per share, excluding intangible asset amortization expense and other specified items, were
$1.15 in the first quarter, up 22.3 percent. Diluted earnings per share were$0.83 on a GAAP basis, including a$298 million foreign exchange loss related to a devaluation ofAbbVie's net monetary assets denominated in the Venezuelan bolivar.
Key Events from the First Quarter
The U.S. Food and Drug Administration (FDA ) approved IMBRUVICA® (ibrutinib) as a first-line therapy for the treatment of chronic lymphocytic leukemia (CLL). This approval was based on data from the Phase 3 RESONATE™-2 trial, which found that treatment with IMBRUVICA significantly decreased the risk of progression or death (progression-free survival, PFS) versus chlorambucil. Following the approval, the National Comprehensive Cancer Network (NCCN) updated its treatment guidelines, granting IMBRUVICA a category 1 recommendation for certain CLL patients, which is the highest recommendation assigned by the organization. The NCCN treatment guidelines influence prescribing and reimbursement practices in many institutions in the U.S. and internationally. IMBRUVICA is also currently under regulatory review by theEuropean Medicines Agency (EMA) as a first-line therapy option for CLL patients.- On
April 11 ,AbbVie received acceleratedFDA approval of Venclexta™ (venetoclax) for patients with relapsed/refractory (R/R) CLL with chromosome 17p deletion, a condition which is typically associated with a poor prognosis, and found in up to 30 to 50 percent of these previously-treated patients. The approval is based on results from a Phase 2, open-label trial, which found that treatment with Venclexta demonstrated an 80 percent overall response rate (ORR) as monotherapy treatment, including patients that achieved complete remission. This indication is currently under review by the EMA, which validatedAbbVie's Marketing Authorization Application earlier this year. TheFDA also previously granted Breakthrough Therapy designations for venetoclax combination therapy with rituximab for patients with R/R CLL and in combination with hypomethylating agents (HMAs) in patients with untreated (treatment-naïve) acute myeloid leukemia (AML) who are ineligible to receive standard induction therapy (high-dose chemotherapy). AbbVie and Boehringer Ingelheim announced a global collaboration to develop and commercialize risankizumab (BI 655066), an anti-IL-23 monoclonal biologic antibody in Phase 3 development for psoriasis.AbbVie and Boehringer Ingelheim also are evaluating the potential of this biologic therapy in Crohn's disease, psoriatic arthritis and asthma. In addition to the anti-IL-23 antibody,AbbVie gained rights to an anti-CD-40 antibody, BI 655064, currently in Phase 1 development.AbbVie presented new data from its investigational chronic hepatitis C virus (HCV) infection development program for ABT-493 and ABT-530, a once-daily, ribavirin (RBV)-free, pan-genotypic regimen at The International Liver Congress™ (EASL). Results from the SURVEYOR-1 and 2 studies found that with eight weeks of treatment, 97-98 percent of genotype 1-3 (GT1-3) HCV infected patients without cirrhosis treated with the regimen achieved sustained virologic response at 12 weeks post-treatment (SVR12). Additionally, 100 percent of genotype 4-6 (GT4-6) patients without cirrhosis achieved SVR12 with 12 weeks of treatment. SURVEYOR-2 further demonstrated that GT3 patients with compensated cirrhosis (Child-Pugh A), historically considered difficult-to-treat, achieved 100 percent SVR12 with 12 weeks of treatment. Additionally, results from the MAGELLAN-1 study demonstrated that SVR12 was achieved in 95 percent of patients with and without RBV in a modified intent-to-treat analysis, excluding patients who did not achieve SVR for reasons other than virologic failure. Further results fromAbbVie's investigational HCV development program will be presented later in the year and the company anticipates commercialization of the next-generation combination in 2017.AbbVie andNeurocrine Biosciences, Inc. announced positive top-line results from the second of two replicate pivotal Phase 3 clinical trials evaluating the efficacy and safety of elagolix in premenopausal women who suffer pain from endometriosis. Study results demonstrated that after six months of continuous treatment, both doses of elagolix (150 mg once daily and 200 mg twice daily) met the study's co-primary endpoints. Elagolix reduced scores of menstrual pain (dysmenorrhea, DYS) and non-menstrual pelvic pain (NMPP) associated with endometriosis, at month three and month six, as measured by the Daily Assessment of Endometriosis Pain scale. Responder rates for the co-primary endpoints from this second Phase 3 pivotal study are consistent with results from the first Phase 3 pivotal study. The companies also announced the initiation of Phase 3 trials of elagolix for the management of uterine fibroids in the quarter.AbbVie announced that it received CHMP positive opinion for HUMIRA® (adalimumab) for the treatment of pediatric patients aged six years or older, with moderate to severe active Crohn's disease. HUMIRA is currently approved in theEuropean Union (EU) for pediatric patients with severe active Crohn's disease. If the variation to the current marketing authorization for HUMIRA in these patients is approved, it will validate the expanded label in all 28 member states of the EU, as well asIceland ,Liechtenstein andNorway .
Full-Year 2016 Outlook
About
Conference Call
Non-GAAP Financial Results
Financial results for 2015 and 2016 are presented on both a reported and a non-GAAP basis. Reported results were prepared in accordance with GAAP and include all revenue and expenses recognized during the period. Non-GAAP results adjust for certain non-cash items and for factors that are unusual or unpredictable, and exclude those costs, expenses, and other specified items presented in the reconciliation tables later in this release.
Forward-Looking Statements
Some statements in this news release may be forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995. The words "believe," "expect," "anticipate," "project" and similar expressions, among others, generally identify forward-looking statements. AbbVie cautions that these forward-looking statements are subject to risks and uncertainties that may cause actual results to differ materially from those indicated in the forward-looking statements. Such risks and uncertainties include, but are not limited to, challenges to intellectual property, competition from other products, difficulties inherent in the research and development process, adverse litigation or government action, and changes to laws and regulations applicable to our industry. Additional information about the economic, competitive, governmental, technological and other factors that may affect
AbbVie Inc. |
||||||||
Key Product Revenues |
||||||||
Quarter Ended March 31, 2016 |
||||||||
(Unaudited) |
||||||||
% Change vs. 1Q15 |
||||||||
Net Revenues (in millions) |
International |
Total |
||||||
U.S. |
Int'l. |
Total |
U.S. |
Operational |
Reported |
Operational |
Reported |
|
TOTAL NET REVENUES |
$3,494 |
$2,464 |
$5,958 |
31.9% |
11.9% |
3.1% |
22.4% |
18.2% |
Humira |
2,195 |
1,382 |
3,577 |
31.9 |
4.6 |
(4.6) |
19.2 |
14.9 |
Imbruvica |
325 |
56a |
381 |
n/m |
n/m |
n/m |
n/m |
n/m |
Viekira |
125 |
289 |
414 |
(9.3) |
n/m |
n/m |
86.9 |
79.2 |
Lupron |
151 |
39 |
190 |
1.1 |
3.5 |
(7.5) |
1.6 |
(0.8) |
Synagis |
-- |
319 |
319 |
n/a |
2.1 |
(4.6) |
2.1 |
(4.6) |
Synthroid |
182 |
-- |
182 |
(2.4) |
n/a |
n/a |
(2.4) |
(2.4) |
Creon |
150 |
-- |
150 |
18.2 |
n/a |
n/a |
18.2 |
18.2 |
AndroGel |
156 |
-- |
156 |
1.9 |
n/a |
n/a |
1.9 |
1.9 |
Kaletra |
33 |
100 |
133 |
(19.7) |
(18.7) |
(27.9) |
(19.0) |
(26.1) |
Sevoflurane |
17 |
94 |
111 |
(1.4) |
(6.1) |
(13.5) |
(5.5) |
(11.8) |
Duodopa |
7 |
61 |
68 |
n/m |
23.6 |
16.6 |
36.7 |
29.8 |
Note: "Operational" growth reflects the percentage change over the prior year excluding the impact of exchange rate fluctuations. |
n/a = not applicable |
n/m = not meaningful |
a Reflects profit sharing for Imbruvica international revenues. |
AbbVie Inc. |
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Consolidated Statements of Earnings |
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Quarter Ended March 31, 2016 and 2015 |
||||
(Unaudited) (In millions, except per share data) |
||||
First Quarter Ended March 31 |
||||
2016 |
2015 |
|||
Net revenues |
$5,958 |
$5,040 |
||
Cost of products sold |
1,369 |
942 |
||
Selling, general and administrative |
1,355 |
1,473 |
||
Research and development |
946 |
811 |
||
Acquired in-process research and development |
10 |
127 |
||
Total operating cost and expenses |
3,680 |
3,353 |
||
Operating earnings |
2,278 |
1,687 |
||
Interest expense, net |
200 |
126 |
||
Net foreign exchange loss |
302 |
164 |
||
Other expense, net |
- |
1 |
||
Earnings before income tax expense |
1,776 |
1,396 |
||
Income tax expense |
422 |
374 |
||
Net earnings |
$1,354 |
$1,022 |
||
Diluted earnings per share |
$0.83 |
$0.63 |
||
Diluted earnings per share, excluding specified itemsa |
$1.15 |
$0.94 |
||
Weighted-average diluted shares outstanding |
1,625 |
1,608 |
a Refer to the Reconciliation of GAAP Reported to Non-GAAP Adjusted Information for further details. |
AbbVie Inc. |
||||
Reconciliation of GAAP Reported to Non-GAAP Adjusted Information |
||||
Quarter Ended March 31, 2016 |
||||
(Unaudited) (In millions, except per share data) |
||||
1. |
Specified items impacted results as follows: |
|||
1Q16 |
||||
Earnings |
Diluted |
|||
Pre-tax |
After-tax |
EPS |
||
As reported (GAAP) |
$1,776 |
$1,354 |
$0.83 |
|
Adjusted for specified items: |
||||
Intangible asset amortization |
165 |
133 |
0.08 |
|
Pharmacyclics acquisition related costs |
57 |
35 |
0.02 |
|
Foreign exchange loss |
298 |
298 |
0.18 |
|
Other |
67 |
54 |
0.04 |
|
As adjusted (non-GAAP) |
$2,363 |
$1,874 |
$1.15 |
|
Intangible asset amortization reflects costs recognized as a result of licensing and acquisition activities. Pharmacyclics acquisition related costs reflect the amortization of the acquisition date fair value step-up for inventory as well as integration and other costs related to the acquisition of Pharmacyclics. The foreign exchange loss relates to a devaluation of AbbVie's net monetary assets denominated in the Venezuelan bolivar. Other is primarily associated with the impairment of an intangible asset and a milestone payment for a previously announced collaboration. |
|
2. |
The impact of the specified items by line item was as follows: |
1Q16 |
||||||
Cost of |
SG&A |
R&D |
Acquired IPR&D |
Net foreign |
||
As reported (GAAP) |
$1,369 |
$1,355 |
$946 |
$10 |
$302 |
|
Adjusted for specified items: |
||||||
Intangible asset amortization |
(165) |
-- |
-- |
-- |
-- |
|
Pharmacyclics acquisition related costs |
(45) |
(4) |
(8) |
-- |
-- |
|
Venezuela devaluation loss |
-- |
-- |
-- |
-- |
(298) |
|
Other |
(44) |
(4) |
(9) |
(10) |
-- |
|
As adjusted (non-GAAP) |
$1,115 |
$1,347 |
929 |
-- |
4 |
|
3. |
The adjusted tax rate for the first quarter of 2016 was 20.7 percent, as detailed below: |
1Q16 |
||||
Pre-tax |
Income |
|||
income |
taxes |
Tax rate |
||
As reported (GAAP) |
$1,776 |
$422 |
23.7% |
|
Specified items |
587 |
67 |
11.4% |
|
As adjusted (non-GAAP) |
$2,363 |
$489 |
20.7% |
AbbVie Inc. |
||||
Reconciliation of GAAP Reported to Non-GAAP Adjusted Information |
||||
Quarter Ended March 31, 2015 |
||||
(Unaudited) (In millions, except per share data) |
||||
1. |
Specified items impacted results as follows: |
|||
1Q15 |
||||
Earnings |
Diluted |
|||
Pre-tax |
After-tax |
EPS |
||
As reported (GAAP) |
$1,396 |
$1,022 |
$0.63 |
|
Adjusted for specified items: |
||||
Intangible asset amortization |
68 |
52 |
0.03 |
|
Separation costs |
104 |
89 |
0.05 |
|
Acquired IPR&D |
127 |
127 |
0.08 |
|
Shire termination |
170 |
170 |
0.11 |
|
Other |
95 |
63 |
0.04 |
|
As adjusted (non-GAAP) |
$1,960 |
$1,523 |
$0.94 |
Intangible asset amortization reflects costs recognized as a result of licensing and acquisition activities. Separation costs are expenses related to the separation of AbbVie from Abbott. Acquired IPR&D primarily reflects the C2N collaboration. Shire termination reflects the completed liquidation of remaining foreign currency positions related to the terminated Shire transaction. Other is primarily associated with restructuring activities and interest expense for the Pharmacyclics acquisition. |
|
2. |
The impact of the specified items by line item was as follows: |
1Q15 |
||||||
Cost of |
SG&A |
Acquired IPR&D |
Interest |
Net foreign |
||
As reported (GAAP) |
$942 |
$1,473 |
$127 |
$126 |
$164 |
|
Adjusted for specified items: |
||||||
Intangible asset amortization |
(68) |
-- |
-- |
-- |
-- |
|
Separation costs |
(3) |
(101) |
-- |
-- |
-- |
|
Acquired IPR&D |
-- |
-- |
(127) |
-- |
-- |
|
Shire termination |
-- |
-- |
-- |
-- |
(170) |
|
Other |
(9) |
(27) |
-- |
(59) |
-- |
|
As adjusted (non-GAAP) |
$862 |
$1,345 |
-- |
$67 |
($6) |
3. |
The adjusted tax rate for the first quarter of 2015 was 22.3 percent, as detailed below: |
1Q15 |
||||
Pre-tax |
Income |
|||
income |
taxes |
Tax rate |
||
As reported (GAAP) |
$1,396 |
$374 |
26.8% |
|
Specified items |
564 |
63 |
11.2% |
|
As adjusted (non-GAAP) |
$1,960 |
$437 |
22.3% |
To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/abbvie-reports-first-quarter-2016-financial-results-300259266.html
SOURCE
Media: Adelle Infante, (847) 938-8745, Investors: Larry Peepo, (847) 935-6722, Liz Shea, (847) 935-2211