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  <xs:element id="abbv_ProbabilityofPaymentforRoyaltiesbyIndicationMember" abstract="true" name="ProbabilityofPaymentforRoyaltiesbyIndicationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="abbv_EpkinlyMember" abstract="true" name="EpkinlyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="abbv_AcquisitionsCollaborationsAndOtherArrangementsDisclosureAbstract" abstract="true" name="AcquisitionsCollaborationsAndOtherArrangementsDisclosureAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="abbv_ProjectedYearofPaymentsMember" abstract="true" name="ProjectedYearofPaymentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="abbv_A5.05SeniorNotesDue2034Member" abstract="true" name="A5.05SeniorNotesDue2034Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="abbv_OtherRestructuringPlansMember" abstract="true" name="OtherRestructuringPlansMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="abbv_ImbruvicaMember" abstract="true" name="ImbruvicaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="abbv_RestructuringCostsLocationAxis" abstract="true" name="RestructuringCostsLocationAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="abbv_UbrelvyMember" abstract="true" name="UbrelvyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="abbv_ProductLiabilityOtherLitigationInStateCourtMember" abstract="true" name="ProductLiabilityOtherLitigationInStateCourtMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="abbv_RestasisMember" abstract="true" name="RestasisMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="abbv_TreasuryLockCashFlowHedgeGainLosstobeReclassifiedDuringNext12MonthsNet" abstract="false" name="TreasuryLockCashFlowHedgeGainLosstobeReclassifiedDuringNext12MonthsNet" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="abbv_SeniorEuroNotesDue2024At1.375Member" abstract="true" name="SeniorEuroNotesDue2024At1.375Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="abbv_CostofGoodsAndServicesSoldFromCollaborativeArrangements" abstract="false" name="CostofGoodsAndServicesSoldFromCollaborativeArrangements" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="abbv_CollaborativeArrangementsPercentageOfShareOfDevelopmentCosts" abstract="false" name="CollaborativeArrangementsPercentageOfShareOfDevelopmentCosts" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="abbv_PrincipalUSCustomersMember" abstract="true" name="PrincipalUSCustomersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="abbv_ImmunoGenMember" abstract="true" name="ImmunoGenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="abbv_AllerganIntegrationPlanMember" abstract="true" name="AllerganIntegrationPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="abbv_StockRepurchaseProgramIncreaseInAuthorizedAmount" abstract="false" name="StockRepurchaseProgramIncreaseInAuthorizedAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="abbv_NumberOfPrincipalUSCustomers" abstract="false" name="NumberOfPrincipalUSCustomers" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="abbv_OtherCollaborationArrangementsMember" abstract="false" name="OtherCollaborationArrangementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="abbv_JuvedermCollectionMember" abstract="true" name="JuvedermCollectionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="abbv_AccumulatedNetGainLossFromNetInvestmentHedgesMember" abstract="true" name="AccumulatedNetGainLossFromNetInvestmentHedgesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="abbv_RestructuringCostsLocationDomain" abstract="true" name="RestructuringCostsLocationDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="abbv_QuliptaMember" abstract="true" name="QuliptaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="abbv_A4.95SeniorNotesDue2031Member" abstract="true" name="A4.95SeniorNotesDue2031Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="abbv_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossAfterReclassificationandTax" abstract="false" name="OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossAfterReclassificationandTax" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="abbv_ProductLiabilityOtherLitigationMember" abstract="true" name="ProductLiabilityOtherLitigationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="abbv_A5.35SeniorNotesDue2044Member" abstract="true" name="A5.35SeniorNotesDue2044Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="abbv_BystolicAntitrustLitigationMember" abstract="true" name="BystolicAntitrustLitigationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="abbv_DefinedBenefitPlanAmortizationOfActuarialGainLossPriorServiceCostCredit" abstract="false" name="DefinedBenefitPlanAmortizationOfActuarialGainLossPriorServiceCostCredit" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="abbv_SeniorNotesDue2023At2.850PercentMember" abstract="true" name="SeniorNotesDue2023At2.850PercentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
