<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:73cde431-e576-43eb-8ced-8cd53de8ffd2,g:2a62c478-7263-4f4e-b7d3-e8971142cc50-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.abbvie.com/role/DocumentandEntityInformationDocument" xlink:type="simple" xlink:href="abbv-20240105.xsd#DocumentandEntityInformationDocument"/>
  <link:definitionLink xlink:role="http://www.abbvie.com/role/DocumentandEntityInformationDocument" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_4cb73bc7-74cf-43d7-aae7-ab6dd9f040b9" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_DocumentType_4cb73bc7-74cf-43d7-aae7-ab6dd9f040b9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_9a805471-e507-4411-a60f-9e0c2e39c427" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_DocumentPeriodEndDate_9a805471-e507-4411-a60f-9e0c2e39c427" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_374d4237-3af5-404c-9788-8384c32100c9" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_EntityRegistrantName_374d4237-3af5-404c-9788-8384c32100c9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_b2807035-3dcf-4a01-88f4-c69133d12336" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_EntityCentralIndexKey_b2807035-3dcf-4a01-88f4-c69133d12336" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_71120de5-6f6c-4bda-89db-6e655c8f7d73" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_AmendmentFlag_71120de5-6f6c-4bda-89db-6e655c8f7d73" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_f9f00f94-4a43-4e29-816b-ab0ea72fa10a" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_EntityIncorporationStateCountryCode_f9f00f94-4a43-4e29-816b-ab0ea72fa10a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_553f249e-2445-4fe4-82d1-25dc0918e2f6" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_EntityFileNumber_553f249e-2445-4fe4-82d1-25dc0918e2f6" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_fb720ec2-e297-4017-81d5-b3af6d181b2f" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_EntityTaxIdentificationNumber_fb720ec2-e297-4017-81d5-b3af6d181b2f" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_3f22a29f-c96b-4ade-a05f-64efb1c17396" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_EntityAddressAddressLine1_3f22a29f-c96b-4ade-a05f-64efb1c17396" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_b0b2cdff-02e1-4338-8cfe-a24dcd4acc7b" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_EntityAddressCityOrTown_b0b2cdff-02e1-4338-8cfe-a24dcd4acc7b" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_4fe84d6f-7b32-4c1e-88e2-5418440e10ba" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressStateOrProvince"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_EntityAddressStateOrProvince_4fe84d6f-7b32-4c1e-88e2-5418440e10ba" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_d486181d-8f05-4520-adf6-b79b535db590" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_EntityAddressPostalZipCode_d486181d-8f05-4520-adf6-b79b535db590" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_c7703756-d06c-4bdd-baba-74dba03753fa" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_CityAreaCode_c7703756-d06c-4bdd-baba-74dba03753fa" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_26b5cf9d-dafe-4e7f-8cb3-ce99a5c44ba1" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_LocalPhoneNumber_26b5cf9d-dafe-4e7f-8cb3-ce99a5c44ba1" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_ff339a88-3f05-4575-9622-3f74e09416fb" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_WrittenCommunications"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_WrittenCommunications_ff339a88-3f05-4575-9622-3f74e09416fb" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_1748ef5c-eb5f-455e-8069-58c9f43c4565" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SolicitingMaterial"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_SolicitingMaterial_1748ef5c-eb5f-455e-8069-58c9f43c4565" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_3cc92fd3-609a-4ee3-8076-a599f1289b60" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementTenderOffer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_PreCommencementTenderOffer_3cc92fd3-609a-4ee3-8076-a599f1289b60" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_79452526-9424-4035-8ec0-6b909d5078ac" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_79452526-9424-4035-8ec0-6b909d5078ac" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_f34aaf43-005d-4291-8e87-03ee52b69dc2" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_Security12bTitle_f34aaf43-005d-4291-8e87-03ee52b69dc2" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_feb42205-7bd7-4134-98d0-446135a3fc23" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_TradingSymbol_feb42205-7bd7-4134-98d0-446135a3fc23" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_32698a07-5d51-4ef4-a362-d69524ceb9e5" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_SecurityExchangeName_32698a07-5d51-4ef4-a362-d69524ceb9e5" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_59fae40b-4743-4c87-bbce-13d2f6a8831e" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_EntityEmergingGrowthCompany_59fae40b-4743-4c87-bbce-13d2f6a8831e" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_504c284a-f02d-497c-a85c-44696d94a711" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_EntityInformationLineItems_c64ca687-4236-41e9-a841-a7a800d37b7e" xlink:to="loc_dei_EntitiesTable_504c284a-f02d-497c-a85c-44696d94a711" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_72410f28-c510-424d-84c8-92a148393de1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_EntitiesTable_504c284a-f02d-497c-a85c-44696d94a711" xlink:to="loc_us-gaap_StatementClassOfStockAxis_72410f28-c510-424d-84c8-92a148393de1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_72410f28-c510-424d-84c8-92a148393de1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_72410f28-c510-424d-84c8-92a148393de1" xlink:to="loc_us-gaap_ClassOfStockDomain_72410f28-c510-424d-84c8-92a148393de1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_c9432481-f430-48bd-a404-ddd08c259ea3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_72410f28-c510-424d-84c8-92a148393de1" xlink:to="loc_us-gaap_ClassOfStockDomain_c9432481-f430-48bd-a404-ddd08c259ea3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_119e5ed7-7627-4794-bfa2-f51039dadc1c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_c9432481-f430-48bd-a404-ddd08c259ea3" xlink:to="loc_us-gaap_CommonStockMember_119e5ed7-7627-4794-bfa2-f51039dadc1c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_Sec1.375SeniorNotesDue2024Member_0cc0107b-3c4f-4ef3-b79b-d540ee103e0e" xlink:href="abbv-20240105.xsd#abbv_Sec1.375SeniorNotesDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_c9432481-f430-48bd-a404-ddd08c259ea3" xlink:to="loc_abbv_Sec1.375SeniorNotesDue2024Member_0cc0107b-3c4f-4ef3-b79b-d540ee103e0e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_Sec1250SeniorNotesDue2024Member_f3d75714-6108-48fe-bcf0-4b6dd4ddf65d" xlink:href="abbv-20240105.xsd#abbv_Sec1250SeniorNotesDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_c9432481-f430-48bd-a404-ddd08c259ea3" xlink:to="loc_abbv_Sec1250SeniorNotesDue2024Member_f3d75714-6108-48fe-bcf0-4b6dd4ddf65d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_Sec0.750SeniorNotesDue2027Member_d22d8b77-763e-42de-b774-dfd92ca8384c" xlink:href="abbv-20240105.xsd#abbv_Sec0.750SeniorNotesDue2027Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_c9432481-f430-48bd-a404-ddd08c259ea3" xlink:to="loc_abbv_Sec0.750SeniorNotesDue2027Member_d22d8b77-763e-42de-b774-dfd92ca8384c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_Sec2.125SeniorNotesdue2028Member_01190041-9998-4d2d-a83d-dc7b463737f8" xlink:href="abbv-20240105.xsd#abbv_Sec2.125SeniorNotesdue2028Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_c9432481-f430-48bd-a404-ddd08c259ea3" xlink:to="loc_abbv_Sec2.125SeniorNotesdue2028Member_01190041-9998-4d2d-a83d-dc7b463737f8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_Sec2625SeniorNotesDue2028Member_bec20e3b-262f-4a36-b71f-52117f5ea299" xlink:href="abbv-20240105.xsd#abbv_Sec2625SeniorNotesDue2028Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_c9432481-f430-48bd-a404-ddd08c259ea3" xlink:to="loc_abbv_Sec2625SeniorNotesDue2028Member_bec20e3b-262f-4a36-b71f-52117f5ea299" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_Sec2125SeniorNotesDue2029Member_d7998ffb-0dcf-42a2-af0c-763c630aa38a" xlink:href="abbv-20240105.xsd#abbv_Sec2125SeniorNotesDue2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_c9432481-f430-48bd-a404-ddd08c259ea3" xlink:to="loc_abbv_Sec2125SeniorNotesDue2029Member_d7998ffb-0dcf-42a2-af0c-763c630aa38a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_Sec1.250SeniorNotesdue2031Member_81ad3e82-ae3c-4425-8693-87f5f1953848" xlink:href="abbv-20240105.xsd#abbv_Sec1.250SeniorNotesdue2031Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_c9432481-f430-48bd-a404-ddd08c259ea3" xlink:to="loc_abbv_Sec1.250SeniorNotesdue2031Member_81ad3e82-ae3c-4425-8693-87f5f1953848" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityListingsExchangeAxis_47f661e8-9a5b-406f-9709-b9d9f44d5b4f" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityListingsExchangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_EntitiesTable_504c284a-f02d-497c-a85c-44696d94a711" xlink:to="loc_dei_EntityListingsExchangeAxis_47f661e8-9a5b-406f-9709-b9d9f44d5b4f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_ExchangeDomain_47f661e8-9a5b-406f-9709-b9d9f44d5b4f_default" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_ExchangeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_EntityListingsExchangeAxis_47f661e8-9a5b-406f-9709-b9d9f44d5b4f" xlink:to="loc_dei_ExchangeDomain_47f661e8-9a5b-406f-9709-b9d9f44d5b4f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_ExchangeDomain_cd8e7bca-87e9-4656-a23b-bea9e7c48bca" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_ExchangeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_EntityListingsExchangeAxis_47f661e8-9a5b-406f-9709-b9d9f44d5b4f" xlink:to="loc_dei_ExchangeDomain_cd8e7bca-87e9-4656-a23b-bea9e7c48bca" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_exch_XNYS_bf669995-bb45-4935-8c79-5854b6660c3e" xlink:href="https://xbrl.sec.gov/exch/2023/exch-2023.xsd#exch_XNYS"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_ExchangeDomain_cd8e7bca-87e9-4656-a23b-bea9e7c48bca" xlink:to="loc_exch_XNYS_bf669995-bb45-4935-8c79-5854b6660c3e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_exch_XCHI_21bb0536-0c09-4443-9759-e3998770d8c0" xlink:href="https://xbrl.sec.gov/exch/2023/exch-2023.xsd#exch_XCHI"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_ExchangeDomain_cd8e7bca-87e9-4656-a23b-bea9e7c48bca" xlink:to="loc_exch_XCHI_21bb0536-0c09-4443-9759-e3998770d8c0" xlink:type="arc" order="1"/>
  </link:definitionLink>
</link:linkbase>
