<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2023 Workiva-->
<!--r:957bb799-1efb-4aa6-ae70-0a004ceedce9,g:bf3aefed-9275-4d51-a56e-16401f7064a0-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.abbvie.com/role/ConsolidatedStatementsofEarnings" xlink:type="simple" xlink:href="abbv-20221231.xsd#ConsolidatedStatementsofEarnings"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/ConsolidatedStatementsofEarnings" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_fca8794b-d1f3-4d3e-845e-c51fda1b184d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_84f2ff70-8b3f-4f7c-8838-b6f950d741a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_fca8794b-d1f3-4d3e-845e-c51fda1b184d" xlink:to="loc_us-gaap_OperatingIncomeLoss_84f2ff70-8b3f-4f7c-8838-b6f950d741a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_6eb677b3-c826-499d-86b7-42bf7ec12908" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_fca8794b-d1f3-4d3e-845e-c51fda1b184d" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_6eb677b3-c826-499d-86b7-42bf7ec12908" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_9e77b215-2850-4be7-93b4-09c8a95e8c73" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_fca8794b-d1f3-4d3e-845e-c51fda1b184d" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_9e77b215-2850-4be7-93b4-09c8a95e8c73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_e1e34cad-d145-45ee-8753-b736ebcdb638" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_fca8794b-d1f3-4d3e-845e-c51fda1b184d" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_e1e34cad-d145-45ee-8753-b736ebcdb638" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_57a86ee8-68e0-465f-9143-27130f28353a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_24289cb5-68fc-42fa-a98b-ba37ef4429ac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_57a86ee8-68e0-465f-9143-27130f28353a" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_24289cb5-68fc-42fa-a98b-ba37ef4429ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_5e44acd2-78ad-43de-98c7-9eaa72bb6d45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_57a86ee8-68e0-465f-9143-27130f28353a" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_5e44acd2-78ad-43de-98c7-9eaa72bb6d45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_4c9f0613-62c3-4690-a1a5-bd5e91efe9b8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_57a86ee8-68e0-465f-9143-27130f28353a" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_4c9f0613-62c3-4690-a1a5-bd5e91efe9b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_43bee206-0822-4897-b8ef-a8390d72f8b4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_57a86ee8-68e0-465f-9143-27130f28353a" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_43bee206-0822-4897-b8ef-a8390d72f8b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingIncomeExpenseNet_3b75afa8-acc9-4e6b-a204-50fc979cce04" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherOperatingIncomeExpenseNet"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_57a86ee8-68e0-465f-9143-27130f28353a" xlink:to="loc_us-gaap_OtherOperatingIncomeExpenseNet_3b75afa8-acc9-4e6b-a204-50fc979cce04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_8dc7fdab-3cd1-4e10-a223-7feccba7b6e1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_9ce50906-d73d-4d94-812d-2b7ec5e2060c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_8dc7fdab-3cd1-4e10-a223-7feccba7b6e1" xlink:to="loc_us-gaap_CostsAndExpenses_9ce50906-d73d-4d94-812d-2b7ec5e2060c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_6b8e7980-1141-4140-96c3-263954ef3cb6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_8dc7fdab-3cd1-4e10-a223-7feccba7b6e1" xlink:to="loc_us-gaap_Revenues_6b8e7980-1141-4140-96c3-263954ef3cb6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_a9395afa-b0c6-44d3-b684-66cf1d8f6599" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_fe2f5f50-92c5-4ee1-9dfb-cf8363652399" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_a9395afa-b0c6-44d3-b684-66cf1d8f6599" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_fe2f5f50-92c5-4ee1-9dfb-cf8363652399" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_15cc77e2-1cc5-4bba-8749-4de7383c3531" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_a9395afa-b0c6-44d3-b684-66cf1d8f6599" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_15cc77e2-1cc5-4bba-8749-4de7383c3531" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_3d56fc8d-9918-4d0b-9d03-707eeaaf83d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_bc2ef305-0873-4549-85a2-8fddf481dbdd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_3d56fc8d-9918-4d0b-9d03-707eeaaf83d6" xlink:to="loc_us-gaap_ProfitLoss_bc2ef305-0873-4549-85a2-8fddf481dbdd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_50c88045-654c-452d-9aa4-213591d8de22" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_3d56fc8d-9918-4d0b-9d03-707eeaaf83d6" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_50c88045-654c-452d-9aa4-213591d8de22" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/ConsolidatedStatementsofComprehensiveIncome" xlink:type="simple" xlink:href="abbv-20221231.xsd#ConsolidatedStatementsofComprehensiveIncome"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/ConsolidatedStatementsofComprehensiveIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_acf18256-9d10-4e35-8482-7f3be90fb043" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_fee82db4-bc2d-434e-a49b-fb3f0647871a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_acf18256-9d10-4e35-8482-7f3be90fb043" xlink:to="loc_us-gaap_ProfitLoss_fee82db4-bc2d-434e-a49b-fb3f0647871a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_10ea968f-cc41-4c77-9416-9626b6dc4f58" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_acf18256-9d10-4e35-8482-7f3be90fb043" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_10ea968f-cc41-4c77-9416-9626b6dc4f58" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_51d43298-43c3-4053-8e27-c7eb66000609" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_2d30b10d-4288-450b-8d01-bb1ea5164e32" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_51d43298-43c3-4053-8e27-c7eb66000609" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentNetOfTax_2d30b10d-4288-450b-8d01-bb1ea5164e32" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_bbcfab1a-ab2d-4864-9788-4bfdd8696ed1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_51d43298-43c3-4053-8e27-c7eb66000609" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_bbcfab1a-ab2d-4864-9788-4bfdd8696ed1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossAfterReclassificationandTax_4bb8a8f4-39e2-4af4-a7d2-d13a8db31723" xlink:href="abbv-20221231.xsd#abbv_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossAfterReclassificationandTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_51d43298-43c3-4053-8e27-c7eb66000609" xlink:to="loc_abbv_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossAfterReclassificationandTax_4bb8a8f4-39e2-4af4-a7d2-d13a8db31723" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_8e79f297-5139-4a49-96e4-c85b76556dc5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_51d43298-43c3-4053-8e27-c7eb66000609" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_8e79f297-5139-4a49-96e4-c85b76556dc5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_bf873149-4d57-4662-a591-a2fc58f9bf74" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_5b4ec805-cd4c-4cd8-b7a3-ecb8d9d61498" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_bf873149-4d57-4662-a591-a2fc58f9bf74" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_5b4ec805-cd4c-4cd8-b7a3-ecb8d9d61498" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_2a90e1b3-a1b4-45d6-9d75-e99d2c6c4b8d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_bf873149-4d57-4662-a591-a2fc58f9bf74" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest_2a90e1b3-a1b4-45d6-9d75-e99d2c6c4b8d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="abbv-20221231.xsd#ConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_0cb3dfed-612d-41f5-b2d9-112e4be47bea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_558b6363-29a0-4acc-8c76-6fadda901927" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_0cb3dfed-612d-41f5-b2d9-112e4be47bea" xlink:to="loc_us-gaap_LiabilitiesCurrent_558b6363-29a0-4acc-8c76-6fadda901927" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_f0371d4b-4276-40fb-8f51-1dad6bd9441b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_0cb3dfed-612d-41f5-b2d9-112e4be47bea" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_f0371d4b-4276-40fb-8f51-1dad6bd9441b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_d981165d-b2e0-46ab-bc4a-2fac971ca925" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_0cb3dfed-612d-41f5-b2d9-112e4be47bea" xlink:to="loc_us-gaap_CommitmentsAndContingencies_d981165d-b2e0-46ab-bc4a-2fac971ca925" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_362422fc-46b4-4135-8049-27ccd4d157a9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_0cb3dfed-612d-41f5-b2d9-112e4be47bea" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_362422fc-46b4-4135-8049-27ccd4d157a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_e5a18b68-d8f5-418b-97b8-806807b24fcb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_0cb3dfed-612d-41f5-b2d9-112e4be47bea" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_e5a18b68-d8f5-418b-97b8-806807b24fcb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_a09e9e12-19eb-40af-b13e-dba640e5d0fa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_0cb3dfed-612d-41f5-b2d9-112e4be47bea" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_a09e9e12-19eb-40af-b13e-dba640e5d0fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_75899158-c49b-4085-8be5-513c0e023d91" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_0937b163-a982-4133-9db3-9e369b079fa7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_75899158-c49b-4085-8be5-513c0e023d91" xlink:to="loc_us-gaap_AssetsCurrent_0937b163-a982-4133-9db3-9e369b079fa7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermInvestments_541e7041-e58d-46f0-af1d-9a9b9fd63bc0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_75899158-c49b-4085-8be5-513c0e023d91" xlink:to="loc_us-gaap_LongTermInvestments_541e7041-e58d-46f0-af1d-9a9b9fd63bc0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_6a787b67-b5ed-4d10-aaa9-2377348c98ed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_75899158-c49b-4085-8be5-513c0e023d91" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_6a787b67-b5ed-4d10-aaa9-2377348c98ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_a982e742-d98f-4ac3-8a7f-f17274ba0c29" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_75899158-c49b-4085-8be5-513c0e023d91" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_a982e742-d98f-4ac3-8a7f-f17274ba0c29" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_0c4cc0a1-765b-45c9-b2b2-a1b2701bc5a4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_75899158-c49b-4085-8be5-513c0e023d91" xlink:to="loc_us-gaap_Goodwill_0c4cc0a1-765b-45c9-b2b2-a1b2701bc5a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_14b11d6d-b5d4-4a4f-bb44-16aa8caae5e7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_75899158-c49b-4085-8be5-513c0e023d91" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_14b11d6d-b5d4-4a4f-bb44-16aa8caae5e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_3ad51583-a308-4eac-8741-2dd41335f2d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermBorrowings_179f92bc-4ba1-4f97-b7bf-4213560e5e7e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortTermBorrowings"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_3ad51583-a308-4eac-8741-2dd41335f2d1" xlink:to="loc_us-gaap_ShortTermBorrowings_179f92bc-4ba1-4f97-b7bf-4213560e5e7e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent_f97d7dcb-1004-4744-8b54-48aaa7d60c1b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_3ad51583-a308-4eac-8741-2dd41335f2d1" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent_f97d7dcb-1004-4744-8b54-48aaa7d60c1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_30ab3fae-af79-4f64-a70f-bc28126dbcd5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_3ad51583-a308-4eac-8741-2dd41335f2d1" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_30ab3fae-af79-4f64-a70f-bc28126dbcd5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_422ee9fa-9e33-42e2-b38a-c8c1333120dd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValueOutstanding_0f8d9c72-f76b-4bdf-89cf-08418bd07b45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValueOutstanding"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_422ee9fa-9e33-42e2-b38a-c8c1333120dd" xlink:to="loc_us-gaap_CommonStockValueOutstanding_0f8d9c72-f76b-4bdf-89cf-08418bd07b45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_a6deab8a-d7ff-4993-a2ec-ead480f71309" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_422ee9fa-9e33-42e2-b38a-c8c1333120dd" xlink:to="loc_us-gaap_TreasuryStockValue_a6deab8a-d7ff-4993-a2ec-ead480f71309" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_fd2a4e54-936d-49c6-baf3-03c21bffa23a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_422ee9fa-9e33-42e2-b38a-c8c1333120dd" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_fd2a4e54-936d-49c6-baf3-03c21bffa23a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_e98302b4-b8db-49f9-a1ab-8b2ab3e3d0bf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_422ee9fa-9e33-42e2-b38a-c8c1333120dd" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_e98302b4-b8db-49f9-a1ab-8b2ab3e3d0bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_ef47909f-c165-4ab8-b992-98ebc6f3d07e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_422ee9fa-9e33-42e2-b38a-c8c1333120dd" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_ef47909f-c165-4ab8-b992-98ebc6f3d07e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_f13c81bb-b7d3-4864-a9ce-520a82d43edc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterest_3928e4ab-e981-4e45-9c8c-f4204ee63e52" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_f13c81bb-b7d3-4864-a9ce-520a82d43edc" xlink:to="loc_us-gaap_MinorityInterest_3928e4ab-e981-4e45-9c8c-f4204ee63e52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_c34a1ae2-9f65-4ad8-9ffe-bb32d07a3f12" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_f13c81bb-b7d3-4864-a9ce-520a82d43edc" xlink:to="loc_us-gaap_StockholdersEquity_c34a1ae2-9f65-4ad8-9ffe-bb32d07a3f12" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_0359efaa-db32-4a71-92be-46d4123a3723" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_514e60b9-c6b2-4b1c-9651-8c913151f193" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_0359efaa-db32-4a71-92be-46d4123a3723" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_514e60b9-c6b2-4b1c-9651-8c913151f193" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_5f7596f4-22c2-4111-98d8-1a5b10c9a787" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_0359efaa-db32-4a71-92be-46d4123a3723" xlink:to="loc_us-gaap_ShortTermInvestments_5f7596f4-22c2-4111-98d8-1a5b10c9a787" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_b13acbfd-10e5-4be6-b580-91ade9351966" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_0359efaa-db32-4a71-92be-46d4123a3723" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_b13acbfd-10e5-4be6-b580-91ade9351966" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_3cd227fd-10c8-4da9-b57f-8590e936a177" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_0359efaa-db32-4a71-92be-46d4123a3723" xlink:to="loc_us-gaap_InventoryNet_3cd227fd-10c8-4da9-b57f-8590e936a177" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssets_5646ad61-e420-4648-8eb7-6bcd721fa7c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseAndOtherAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_0359efaa-db32-4a71-92be-46d4123a3723" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssets_5646ad61-e420-4648-8eb7-6bcd721fa7c0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="abbv-20221231.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_941ca48d-20c9-42df-9530-7c15acd995a0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireOtherInvestments_7aabe68a-91d4-4296-bd40-a5c04f544915" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireOtherInvestments"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_941ca48d-20c9-42df-9530-7c15acd995a0" xlink:to="loc_us-gaap_PaymentsToAcquireOtherInvestments_7aabe68a-91d4-4296-bd40-a5c04f544915" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_23054175-8173-4aef-b001-180558c8e641" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_941ca48d-20c9-42df-9530-7c15acd995a0" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_23054175-8173-4aef-b001-180558c8e641" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_eab01546-9baa-4744-a45a-505bfb374a5c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_941ca48d-20c9-42df-9530-7c15acd995a0" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_eab01546-9baa-4744-a45a-505bfb374a5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_57eacb3e-8c80-4817-84bb-f48ed82812ba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_941ca48d-20c9-42df-9530-7c15acd995a0" xlink:to="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_57eacb3e-8c80-4817-84bb-f48ed82812ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_3c68d937-f781-46ee-9667-7f7c167b22e5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_941ca48d-20c9-42df-9530-7c15acd995a0" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_3c68d937-f781-46ee-9667-7f7c167b22e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_8534bb96-d65a-4fc4-bca9-bcb88732b317" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_941ca48d-20c9-42df-9530-7c15acd995a0" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_8534bb96-d65a-4fc4-bca9-bcb88732b317" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_642fe0e6-5938-4029-9b9c-4df73de5b508" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:to="loc_us-gaap_ProfitLoss_642fe0e6-5938-4029-9b9c-4df73de5b508" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_dcb0d5b5-2035-4786-98b8-74ad2bd4daa5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:to="loc_us-gaap_Depreciation_dcb0d5b5-2035-4786-98b8-74ad2bd4daa5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_736cbb69-af40-43d1-af0e-49a59ff337ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_736cbb69-af40-43d1-af0e-49a59ff337ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_b16cea9d-de6d-4506-ad9d-bbc924e43f6f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_b16cea9d-de6d-4506-ad9d-bbc924e43f6f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_7e936f14-1977-48ae-acd9-4a7a5cfc6e61" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:to="loc_us-gaap_ShareBasedCompensation_7e936f14-1977-48ae-acd9-4a7a5cfc6e61" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_UpfrontCostsRelatedToCollaborations_d1b42a40-4086-40e6-8701-f6416a749bb9" xlink:href="abbv-20221231.xsd#abbv_UpfrontCostsRelatedToCollaborations"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:to="loc_abbv_UpfrontCostsRelatedToCollaborations_d1b42a40-4086-40e6-8701-f6416a749bb9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfOtherAssets_e5f9851b-bbd7-4b74-9682-208b8116c9be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnSaleOfOtherAssets"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:to="loc_us-gaap_GainLossOnSaleOfOtherAssets_e5f9851b-bbd7-4b74-9682-208b8116c9be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_9e2c7add-019d-44a3-8510-f75b961cfab5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_9e2c7add-019d-44a3-8510-f75b961cfab5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_bcf11185-7b59-4dc0-a2ee-df0a91cec7e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_bcf11185-7b59-4dc0-a2ee-df0a91cec7e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_ac19c577-5df5-4761-92f7-b3e4d87ab8bb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_ac19c577-5df5-4761-92f7-b3e4d87ab8bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_6bd91caf-7840-4a28-8ba5-6b3621d3d51e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_6bd91caf-7840-4a28-8ba5-6b3621d3d51e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_1d54e4fc-6c60-4b86-87a7-1c3857024aed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_1d54e4fc-6c60-4b86-87a7-1c3857024aed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_bb81f407-ca3d-4be9-8dfe-1d6afd06fd23" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_bb81f407-ca3d-4be9-8dfe-1d6afd06fd23" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_4e69548f-4e0a-4b9c-92e7-4ea415a3624c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_4e69548f-4e0a-4b9c-92e7-4ea415a3624c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInIncomeTaxesPayableNetOfIncomeTaxesReceivable_29368f27-c459-42d9-94af-61b9a7e8509d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInIncomeTaxesPayableNetOfIncomeTaxesReceivable"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:to="loc_us-gaap_IncreaseDecreaseInIncomeTaxesPayableNetOfIncomeTaxesReceivable_29368f27-c459-42d9-94af-61b9a7e8509d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_NonCashLitigationReserveAdjustmentsNetOfCashPayments_ccc6a708-a08b-41ab-8b5d-866916cb2609" xlink:href="abbv-20221231.xsd#abbv_NonCashLitigationReserveAdjustmentsNetOfCashPayments"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:to="loc_abbv_NonCashLitigationReserveAdjustmentsNetOfCashPayments_ccc6a708-a08b-41ab-8b5d-866916cb2609" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_OtherChargesRelatedToCollaborations_dff23a4d-c889-4307-9c18-b83435676475" xlink:href="abbv-20221231.xsd#abbv_OtherChargesRelatedToCollaborations"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f28e9bec-1164-42d6-b01d-d2e625fd5173" xlink:to="loc_abbv_OtherChargesRelatedToCollaborations_dff23a4d-c889-4307-9c18-b83435676475" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_911eb9b2-6760-4729-b427-dfb5d2bc477c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_7f6abcff-bdf5-4f8a-bd04-15f8939f8687" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_911eb9b2-6760-4729-b427-dfb5d2bc477c" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_7f6abcff-bdf5-4f8a-bd04-15f8939f8687" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebtAndCapitalSecurities_eba4afda-c9d1-479c-97ce-5759d19e14f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RepaymentsOfLongTermDebtAndCapitalSecurities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_911eb9b2-6760-4729-b427-dfb5d2bc477c" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebtAndCapitalSecurities_eba4afda-c9d1-479c-97ce-5759d19e14f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentOfFinancingAndStockIssuanceCosts_7f9ee2c9-a5a2-47cc-b557-4efb2e9e3f6b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentOfFinancingAndStockIssuanceCosts"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_911eb9b2-6760-4729-b427-dfb5d2bc477c" xlink:to="loc_us-gaap_PaymentOfFinancingAndStockIssuanceCosts_7f9ee2c9-a5a2-47cc-b557-4efb2e9e3f6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividends_3dc8a014-9f5e-4f56-9724-32f81a63e675" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsOfDividends"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_911eb9b2-6760-4729-b427-dfb5d2bc477c" xlink:to="loc_us-gaap_PaymentsOfDividends_3dc8a014-9f5e-4f56-9724-32f81a63e675" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_7b34b12d-1671-4adf-bcbe-5441e46a49dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_911eb9b2-6760-4729-b427-dfb5d2bc477c" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_7b34b12d-1671-4adf-bcbe-5441e46a49dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_ad04fca1-b6e3-48e3-8f37-5f4ee46fa1c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_911eb9b2-6760-4729-b427-dfb5d2bc477c" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_ad04fca1-b6e3-48e3-8f37-5f4ee46fa1c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities_bdbda68f-82e4-4001-8a77-16cc7dbd519c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_911eb9b2-6760-4729-b427-dfb5d2bc477c" xlink:to="loc_us-gaap_PaymentForContingentConsiderationLiabilityFinancingActivities_bdbda68f-82e4-4001-8a77-16cc7dbd519c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_3fd1708b-28b4-4c15-b7f9-1e51a90d5049" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_911eb9b2-6760-4729-b427-dfb5d2bc477c" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_3fd1708b-28b4-4c15-b7f9-1e51a90d5049" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_21ef5591-6ab5-48bc-a1ec-0d8f90a9f11a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3a16b56-ddd4-4e83-8d44-0de5a6bd7e5a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_21ef5591-6ab5-48bc-a1ec-0d8f90a9f11a" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a3a16b56-ddd4-4e83-8d44-0de5a6bd7e5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_efdd02f7-e9fc-4c56-a3ad-eac00c2b4a2a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_21ef5591-6ab5-48bc-a1ec-0d8f90a9f11a" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_efdd02f7-e9fc-4c56-a3ad-eac00c2b4a2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_dc9ddd27-8feb-45a9-b8fd-09e4095f6019" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_21ef5591-6ab5-48bc-a1ec-0d8f90a9f11a" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_dc9ddd27-8feb-45a9-b8fd-09e4095f6019" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_ae5dfca2-87b3-4e2b-bf82-cee9bc3910e1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_21ef5591-6ab5-48bc-a1ec-0d8f90a9f11a" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_ae5dfca2-87b3-4e2b-bf82-cee9bc3910e1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/SummaryofSignificantAccountingPoliciesScheduleofInventoriesDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#SummaryofSignificantAccountingPoliciesScheduleofInventoriesDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/SummaryofSignificantAccountingPoliciesScheduleofInventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_0e4fe226-ed6c-4bd0-a77b-4fe4c12b4efe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_51ef2071-9443-403b-929b-b8a7921e9bdc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_0e4fe226-ed6c-4bd0-a77b-4fe4c12b4efe" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_51ef2071-9443-403b-929b-b8a7921e9bdc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_375ca030-89bc-445d-a550-acb19fcfec07" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_0e4fe226-ed6c-4bd0-a77b-4fe4c12b4efe" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_375ca030-89bc-445d-a550-acb19fcfec07" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_ffe6c5b0-a146-4160-938c-6bd1264c601a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_0e4fe226-ed6c-4bd0-a77b-4fe4c12b4efe" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_ffe6c5b0-a146-4160-938c-6bd1264c601a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/SummaryofSignificantAccountingPoliciesScheduleofPropertyandEquipmentNetDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#SummaryofSignificantAccountingPoliciesScheduleofPropertyandEquipmentNetDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/SummaryofSignificantAccountingPoliciesScheduleofPropertyandEquipmentNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_91b55ca4-4435-4c22-8101-036bdfdef02f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_d6b0436d-e381-4f53-90a5-5da7c46d302e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_91b55ca4-4435-4c22-8101-036bdfdef02f" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_d6b0436d-e381-4f53-90a5-5da7c46d302e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_8cae7531-8a32-4e75-b204-17656d398ea4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_91b55ca4-4435-4c22-8101-036bdfdef02f" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_8cae7531-8a32-4e75-b204-17656d398ea4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/SupplementalFinancialInformationDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#SupplementalFinancialInformationDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/SupplementalFinancialInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_eb3a34f2-514e-4638-be97-6b3129a5faeb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_AccruedSalesRebates_9e526548-51fe-4eb1-b732-5f5e0cbaafb4" xlink:href="abbv-20221231.xsd#abbv_AccruedSalesRebates"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_eb3a34f2-514e-4638-be97-6b3129a5faeb" xlink:to="loc_abbv_AccruedSalesRebates_9e526548-51fe-4eb1-b732-5f5e0cbaafb4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPayableCurrent_1aa4f475-226c-4dbc-b6ff-2b2e6c60f5f7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendsPayableCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_eb3a34f2-514e-4638-be97-6b3129a5faeb" xlink:to="loc_us-gaap_DividendsPayableCurrent_1aa4f475-226c-4dbc-b6ff-2b2e6c60f5f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_5a321163-66d0-4de7-bb41-3e63de562069" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_eb3a34f2-514e-4638-be97-6b3129a5faeb" xlink:to="loc_us-gaap_AccountsPayableCurrent_5a321163-66d0-4de7-bb41-3e63de562069" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_294f0d80-5a91-4eb4-81bf-c07c8817b7dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_eb3a34f2-514e-4638-be97-6b3129a5faeb" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_294f0d80-5a91-4eb4-81bf-c07c8817b7dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrent_8d9ec5fc-73b0-47ec-ac51-156f6109a1e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedRoyaltiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_eb3a34f2-514e-4638-be97-6b3129a5faeb" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrent_8d9ec5fc-73b0-47ec-ac51-156f6109a1e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_3fd012b7-b0a0-4fd5-86cc-9624e4c107a0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_eb3a34f2-514e-4638-be97-6b3129a5faeb" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_3fd012b7-b0a0-4fd5-86cc-9624e4c107a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_0ee6039a-9de3-45d5-8ef7-a1ed1c31a4a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_eb3a34f2-514e-4638-be97-6b3129a5faeb" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_0ee6039a-9de3-45d5-8ef7-a1ed1c31a4a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_55f1958a-a39e-4acc-982a-b0f4fb45db87" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_6e7ae37e-f3c9-4d68-b639-ffd06f686068" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_55f1958a-a39e-4acc-982a-b0f4fb45db87" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_6e7ae37e-f3c9-4d68-b639-ffd06f686068" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_UnrecognizedTaxBenefitsLiabilities_ebea103f-c088-4d99-909f-2ac17bc354d3" xlink:href="abbv-20221231.xsd#abbv_UnrecognizedTaxBenefitsLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_55f1958a-a39e-4acc-982a-b0f4fb45db87" xlink:to="loc_abbv_UnrecognizedTaxBenefitsLiabilities_ebea103f-c088-4d99-909f-2ac17bc354d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesNoncurrent_341ba444-aa7d-4fde-a12f-3338157f1172" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedIncomeTaxesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_55f1958a-a39e-4acc-982a-b0f4fb45db87" xlink:to="loc_us-gaap_AccruedIncomeTaxesNoncurrent_341ba444-aa7d-4fde-a12f-3338157f1172" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesNoncurrent_c098ac81-a177-4069-8cee-1adb8b3730d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAccruedLiabilitiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_55f1958a-a39e-4acc-982a-b0f4fb45db87" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesNoncurrent_c098ac81-a177-4069-8cee-1adb8b3730d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_03aeee17-e98e-4d82-94da-0b6d8435ba5b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_55f1958a-a39e-4acc-982a-b0f4fb45db87" xlink:to="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_03aeee17-e98e-4d82-94da-0b6d8435ba5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_5f39b4c7-e0aa-40aa-a8a3-cd9f09afd24c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_09ef2ea2-3bd5-4a1f-abd0-c69dec252344" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_5f39b4c7-e0aa-40aa-a8a3-cd9f09afd24c" xlink:to="loc_us-gaap_InterestExpense_09ef2ea2-3bd5-4a1f-abd0-c69dec252344" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterestAndDividend_777f3eab-2ecf-48b5-bf8e-f7c1a2ebc485" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentIncomeInterestAndDividend"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_5f39b4c7-e0aa-40aa-a8a3-cd9f09afd24c" xlink:to="loc_us-gaap_InvestmentIncomeInterestAndDividend_777f3eab-2ecf-48b5-bf8e-f7c1a2ebc485" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/EarningsPerShareDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#EarningsPerShareDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/EarningsPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_65d99a13-cc50-4674-aca6-533eb8e6e3a6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_6bb5c2c3-9c0d-407c-a424-d46fd54d0575" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_65d99a13-cc50-4674-aca6-533eb8e6e3a6" xlink:to="loc_us-gaap_NetIncomeLoss_6bb5c2c3-9c0d-407c-a424-d46fd54d0575" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ParticipatingSecuritiesDistributedAndUndistributedEarningsLossBasic_f4e69d29-c4b0-4782-afa6-f14b5e960e23" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ParticipatingSecuritiesDistributedAndUndistributedEarningsLossBasic"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_65d99a13-cc50-4674-aca6-533eb8e6e3a6" xlink:to="loc_us-gaap_ParticipatingSecuritiesDistributedAndUndistributedEarningsLossBasic_f4e69d29-c4b0-4782-afa6-f14b5e960e23" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_d5c85d61-306c-4aa0-a44e-2c72cd6c603f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_fc497a4e-b84e-472e-b304-fd9f9cafc71d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_d5c85d61-306c-4aa0-a44e-2c72cd6c603f" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_fc497a4e-b84e-472e-b304-fd9f9cafc71d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_5c88c4ba-36a8-4cc8-a1d4-bef3f4261165" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_d5c85d61-306c-4aa0-a44e-2c72cd6c603f" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_5c88c4ba-36a8-4cc8-a1d4-bef3f4261165" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_8eb20f75-b161-4784-8856-2e0afb740461" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_d66bd41f-0e81-4c28-83c2-76e411f451a6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_8eb20f75-b161-4784-8856-2e0afb740461" xlink:to="loc_us-gaap_NetIncomeLoss_d66bd41f-0e81-4c28-83c2-76e411f451a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ParticipatingSecuritiesDistributedAndUndistributedEarningsLossDiluted_3e051821-1ee9-40bd-8a89-d57a00b82c78" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ParticipatingSecuritiesDistributedAndUndistributedEarningsLossDiluted"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_8eb20f75-b161-4784-8856-2e0afb740461" xlink:to="loc_us-gaap_ParticipatingSecuritiesDistributedAndUndistributedEarningsLossDiluted_3e051821-1ee9-40bd-8a89-d57a00b82c78" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/LicensingAcquisitionsandOtherArrangementsAcquisitionofAllerganDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#LicensingAcquisitionsandOtherArrangementsAcquisitionofAllerganDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/LicensingAcquisitionsandOtherArrangementsAcquisitionofAllerganDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_d0143163-301b-44b6-9259-4c243cbecac2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_9acc0688-6d6b-4cc9-9f81-888a0feb0e32" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_d0143163-301b-44b6-9259-4c243cbecac2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_9acc0688-6d6b-4cc9-9f81-888a0feb0e32" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_38cb0b74-9fa6-4a8e-b849-921a6aa25c14" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_d0143163-301b-44b6-9259-4c243cbecac2" xlink:to="loc_us-gaap_Goodwill_38cb0b74-9fa6-4a8e-b849-921a6aa25c14" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f3d79bd0-51e2-46a9-9c93-fe808f197635" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_67c42fc5-1a86-40ba-9164-c71316e9752e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f3d79bd0-51e2-46a9-9c93-fe808f197635" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_67c42fc5-1a86-40ba-9164-c71316e9752e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_360f71ce-a572-4c25-815b-5df9ac00814b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f3d79bd0-51e2-46a9-9c93-fe808f197635" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_360f71ce-a572-4c25-815b-5df9ac00814b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedLongTermDebtandFinanceLeaseObligations_103937ae-5e66-4d23-ad59-165ef829eae8" xlink:href="abbv-20221231.xsd#abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedLongTermDebtandFinanceLeaseObligations"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f3d79bd0-51e2-46a9-9c93-fe808f197635" xlink:to="loc_abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedLongTermDebtandFinanceLeaseObligations_103937ae-5e66-4d23-ad59-165ef829eae8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_ac65e7a5-a38c-47c7-b497-85c07355e05f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f3d79bd0-51e2-46a9-9c93-fe808f197635" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_ac65e7a5-a38c-47c7-b497-85c07355e05f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedAccountsPayableandAccruedLiabilities_61dfe750-61d8-409e-9894-a16a91842ebd" xlink:href="abbv-20221231.xsd#abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedAccountsPayableandAccruedLiabilities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f3d79bd0-51e2-46a9-9c93-fe808f197635" xlink:to="loc_abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedAccountsPayableandAccruedLiabilities_61dfe750-61d8-409e-9894-a16a91842ebd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_f71a6c22-721a-4af6-b743-cc1e82f5c362" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f3d79bd0-51e2-46a9-9c93-fe808f197635" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_f71a6c22-721a-4af6-b743-cc1e82f5c362" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_6f72900a-b59b-473e-8ace-15390d89f271" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f3d79bd0-51e2-46a9-9c93-fe808f197635" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_6f72900a-b59b-473e-8ace-15390d89f271" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedShortTermInvestments_26fe6171-fffa-42b5-b2a1-d5485f414679" xlink:href="abbv-20221231.xsd#abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedShortTermInvestments"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f3d79bd0-51e2-46a9-9c93-fe808f197635" xlink:to="loc_abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedShortTermInvestments_26fe6171-fffa-42b5-b2a1-d5485f414679" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_6eaa6ed4-a5f8-4dc4-802a-a305bf001a8a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f3d79bd0-51e2-46a9-9c93-fe808f197635" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_6eaa6ed4-a5f8-4dc4-802a-a305bf001a8a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_866937f0-4e5f-4874-bcfe-01e9baae5c8e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f3d79bd0-51e2-46a9-9c93-fe808f197635" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_866937f0-4e5f-4874-bcfe-01e9baae5c8e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_9304fdd8-5959-4ee3-bd27-371a1068cf89" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f3d79bd0-51e2-46a9-9c93-fe808f197635" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_9304fdd8-5959-4ee3-bd27-371a1068cf89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentPortionofLongTermDebtandFinanceObligations_ab2e3e96-89c4-4a45-8d95-00e729f5081b" xlink:href="abbv-20221231.xsd#abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentPortionofLongTermDebtandFinanceObligations"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f3d79bd0-51e2-46a9-9c93-fe808f197635" xlink:to="loc_abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentPortionofLongTermDebtandFinanceObligations_ab2e3e96-89c4-4a45-8d95-00e729f5081b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets_07ab6dd4-d8c6-4a01-a804-135b7f916c73" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f3d79bd0-51e2-46a9-9c93-fe808f197635" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIndefiniteLivedIntangibleAssets_07ab6dd4-d8c6-4a01-a804-135b7f916c73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_b998955d-9184-43cc-8ef8-a011a96c4624" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f3d79bd0-51e2-46a9-9c93-fe808f197635" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_b998955d-9184-43cc-8ef8-a011a96c4624" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_69867bba-66e8-4fc5-9ec9-820f54b789fc" xlink:href="abbv-20221231.xsd#abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f3d79bd0-51e2-46a9-9c93-fe808f197635" xlink:to="loc_abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedInvestments_69867bba-66e8-4fc5-9ec9-820f54b789fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedShortTermBorrowings_09117b0d-c7bb-4f3d-ac90-034e04804b58" xlink:href="abbv-20221231.xsd#abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedShortTermBorrowings"/>
    <link:calculationArc order="16" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f3d79bd0-51e2-46a9-9c93-fe808f197635" xlink:to="loc_abbv_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedShortTermBorrowings_09117b0d-c7bb-4f3d-ac90-034e04804b58" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/GoodwillandIntangibleAssetsSummaryofIntangibleAssetsDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#GoodwillandIntangibleAssetsSummaryofIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/GoodwillandIntangibleAssetsSummaryofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_584d4382-ff2c-46e2-a56b-d82bd3bb614e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_9b57c56c-f6d8-4afc-9b60-d6f54e72a1e7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_584d4382-ff2c-46e2-a56b-d82bd3bb614e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_9b57c56c-f6d8-4afc-9b60-d6f54e72a1e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_adecff77-a0a8-4f37-81e2-0c913a729b42" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_584d4382-ff2c-46e2-a56b-d82bd3bb614e" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_adecff77-a0a8-4f37-81e2-0c913a729b42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_08829095-8783-465b-b3da-8c267732d65d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_f2bcb27b-adfc-49db-bbee-b38490155782" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_08829095-8783-465b-b3da-8c267732d65d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_f2bcb27b-adfc-49db-bbee-b38490155782" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_6072c104-f0a0-4ad5-b850-77c7f25e695e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_08829095-8783-465b-b3da-8c267732d65d" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_6072c104-f0a0-4ad5-b850-77c7f25e695e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6a6acb8a-e9d6-4f88-a31e-e5fdb34a490b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_5e9fd977-9bab-4059-ada3-4d1c30863ca8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6a6acb8a-e9d6-4f88-a31e-e5fdb34a490b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_5e9fd977-9bab-4059-ada3-4d1c30863ca8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_0e23d9d0-aed5-4919-8634-d90dc3f15de1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6a6acb8a-e9d6-4f88-a31e-e5fdb34a490b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_0e23d9d0-aed5-4919-8634-d90dc3f15de1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/GoodwillandIntangibleAssetsSummaryofIntangibleAssetsDetails_1" xlink:type="simple" xlink:href="abbv-20221231.xsd#GoodwillandIntangibleAssetsSummaryofIntangibleAssetsDetails_1"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/GoodwillandIntangibleAssetsSummaryofIntangibleAssetsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_7fbdfec4-8723-4b16-aa3b-a26c9099cb17" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_401a3885-83e1-459a-af10-8d624ec7b181" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_7fbdfec4-8723-4b16-aa3b-a26c9099cb17" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_401a3885-83e1-459a-af10-8d624ec7b181" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_d0450ce0-81da-42cf-aa2c-564df3327ac5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_7fbdfec4-8723-4b16-aa3b-a26c9099cb17" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_d0450ce0-81da-42cf-aa2c-564df3327ac5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/LeasesBalanceSheetDisclosureDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#LeasesBalanceSheetDisclosureDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/LeasesBalanceSheetDisclosureDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LeaseRightofUseAsset_7e0c9062-fc27-4f36-b4c3-7140b91e627e" xlink:href="abbv-20221231.xsd#abbv_LeaseRightofUseAsset"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_0c1f1c50-18af-4fe6-82c1-0fd40b3c5560" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abbv_LeaseRightofUseAsset_7e0c9062-fc27-4f36-b4c3-7140b91e627e" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_0c1f1c50-18af-4fe6-82c1-0fd40b3c5560" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_5ed57fab-bfb3-4101-bde5-b7f44563ed15" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseRightOfUseAsset"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abbv_LeaseRightofUseAsset_7e0c9062-fc27-4f36-b4c3-7140b91e627e" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_5ed57fab-bfb3-4101-bde5-b7f44563ed15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LeaseLiability_21281d1f-e3b8-4d4b-9306-f996b1c75e87" xlink:href="abbv-20221231.xsd#abbv_LeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_7b918d4a-dff4-488c-9488-4ec840b65518" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abbv_LeaseLiability_21281d1f-e3b8-4d4b-9306-f996b1c75e87" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_7b918d4a-dff4-488c-9488-4ec840b65518" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_1d8986ef-46f5-4726-88a3-e752c2e5079f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abbv_LeaseLiability_21281d1f-e3b8-4d4b-9306-f996b1c75e87" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_1d8986ef-46f5-4726-88a3-e752c2e5079f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_c34cf49c-8192-4aa1-9db5-9714f08738d9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abbv_LeaseLiability_21281d1f-e3b8-4d4b-9306-f996b1c75e87" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_c34cf49c-8192-4aa1-9db5-9714f08738d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_b85eb70f-aa79-441e-b08f-9762042906a2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abbv_LeaseLiability_21281d1f-e3b8-4d4b-9306-f996b1c75e87" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_b85eb70f-aa79-441e-b08f-9762042906a2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/LeasesCostDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#LeasesCostDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/LeasesCostDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_2bfbbfc8-abc6-494f-8082-5f99ed9ff6bf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_5df93234-3fa6-4bd8-9fa1-6e45d05474c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_2bfbbfc8-abc6-494f-8082-5f99ed9ff6bf" xlink:to="loc_us-gaap_OperatingLeaseCost_5df93234-3fa6-4bd8-9fa1-6e45d05474c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermLeaseCost_f969f8ca-d3fc-4fed-b159-cca54d3a745d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortTermLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_2bfbbfc8-abc6-494f-8082-5f99ed9ff6bf" xlink:to="loc_us-gaap_ShortTermLeaseCost_f969f8ca-d3fc-4fed-b159-cca54d3a745d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_6aeb355b-2de1-4566-9bc1-0d66ab6a28e1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableLeaseCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_2bfbbfc8-abc6-494f-8082-5f99ed9ff6bf" xlink:to="loc_us-gaap_VariableLeaseCost_6aeb355b-2de1-4566-9bc1-0d66ab6a28e1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/LeasesMaturitiesofLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#LeasesMaturitiesofLeaseLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/LeasesMaturitiesofLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_97957ced-7c4c-4065-8262-a7df82bec7e3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueInNextRollingTwelveMonths_c8c72d2b-2010-4453-a46c-aa14d8f27974" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueInNextRollingTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_97957ced-7c4c-4065-8262-a7df82bec7e3" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueInNextRollingTwelveMonths_c8c72d2b-2010-4453-a46c-aa14d8f27974" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_c1f7b090-619e-4589-9a00-f219b34e3b42" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_97957ced-7c4c-4065-8262-a7df82bec7e3" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_c1f7b090-619e-4589-9a00-f219b34e3b42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_9c4533c9-6b42-4ae1-b06d-fb2806856b5d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_97957ced-7c4c-4065-8262-a7df82bec7e3" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_9c4533c9-6b42-4ae1-b06d-fb2806856b5d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_2ad65e47-4abc-4799-955f-7381cb6cea01" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_97957ced-7c4c-4065-8262-a7df82bec7e3" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_2ad65e47-4abc-4799-955f-7381cb6cea01" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_103e38f6-34a3-4b23-975f-037433d6ced4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_97957ced-7c4c-4065-8262-a7df82bec7e3" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_103e38f6-34a3-4b23-975f-037433d6ced4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_8f16d34b-f75f-443b-b3f8-7c97f7d3d95a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_97957ced-7c4c-4065-8262-a7df82bec7e3" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_8f16d34b-f75f-443b-b3f8-7c97f7d3d95a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LeaseLiabilityPaymentsDue_b5d8f982-599a-4862-ac5d-b2b82f69b8e0" xlink:href="abbv-20221231.xsd#abbv_LeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LeaseLiabilityUndiscountedExcessAmount_1d077e10-537d-41b6-b42b-d8ee5c18b80c" xlink:href="abbv-20221231.xsd#abbv_LeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abbv_LeaseLiabilityPaymentsDue_b5d8f982-599a-4862-ac5d-b2b82f69b8e0" xlink:to="loc_abbv_LeaseLiabilityUndiscountedExcessAmount_1d077e10-537d-41b6-b42b-d8ee5c18b80c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LeaseLiability_5856e7da-e70f-4ee6-a2d1-05293708a038" xlink:href="abbv-20221231.xsd#abbv_LeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abbv_LeaseLiabilityPaymentsDue_b5d8f982-599a-4862-ac5d-b2b82f69b8e0" xlink:to="loc_abbv_LeaseLiability_5856e7da-e70f-4ee6-a2d1-05293708a038" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_e5ba7813-68c9-4660-b6fd-9f6b9be882e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextRollingTwelveMonths_b6d28d7c-db70-4e2d-b7fd-ffad9a3ff7da" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextRollingTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_e5ba7813-68c9-4660-b6fd-9f6b9be882e4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextRollingTwelveMonths_b6d28d7c-db70-4e2d-b7fd-ffad9a3ff7da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_729bf4f7-2570-47c0-9341-a3043456b4dd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_e5ba7813-68c9-4660-b6fd-9f6b9be882e4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_729bf4f7-2570-47c0-9341-a3043456b4dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_511b6dc7-e0e4-4046-9db1-df2cddf25016" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_e5ba7813-68c9-4660-b6fd-9f6b9be882e4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_511b6dc7-e0e4-4046-9db1-df2cddf25016" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_ca1c2b03-e184-414d-99a4-ebd80133ef0c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_e5ba7813-68c9-4660-b6fd-9f6b9be882e4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_ca1c2b03-e184-414d-99a4-ebd80133ef0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_d5d45e76-1587-4fd1-b8e6-1a194ff438a2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_e5ba7813-68c9-4660-b6fd-9f6b9be882e4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_d5d45e76-1587-4fd1-b8e6-1a194ff438a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_6125d262-0663-446b-b3ee-4597789103d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_e5ba7813-68c9-4660-b6fd-9f6b9be882e4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_6125d262-0663-446b-b3ee-4597789103d1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/LeasesMaturitiesofLeaseLiabilitiesDetails_1" xlink:type="simple" xlink:href="abbv-20221231.xsd#LeasesMaturitiesofLeaseLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/LeasesMaturitiesofLeaseLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_973523b3-1239-464d-8c3f-69f7f6264fcc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_c513411e-ec45-4c20-a7cc-bec92f4105be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_973523b3-1239-464d-8c3f-69f7f6264fcc" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_c513411e-ec45-4c20-a7cc-bec92f4105be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_7c7043b6-d054-4c9c-bd67-908613dd2ff9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_973523b3-1239-464d-8c3f-69f7f6264fcc" xlink:to="loc_us-gaap_OperatingLeaseLiability_7c7043b6-d054-4c9c-bd67-908613dd2ff9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LeaseLiabilityPaymentsDue_a2ecab88-0444-4c54-b97b-ab96ae2101a2" xlink:href="abbv-20221231.xsd#abbv_LeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LeaseLiabilityPaymentsDueNextRollingTwelveMonths_a1c47ef2-b4ff-4ba1-9402-7c7cc1b8563a" xlink:href="abbv-20221231.xsd#abbv_LeaseLiabilityPaymentsDueNextRollingTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abbv_LeaseLiabilityPaymentsDue_a2ecab88-0444-4c54-b97b-ab96ae2101a2" xlink:to="loc_abbv_LeaseLiabilityPaymentsDueNextRollingTwelveMonths_a1c47ef2-b4ff-4ba1-9402-7c7cc1b8563a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LeaseLiabilityPaymentsDueYearTwo_3dbf3754-f23c-4082-b1ab-cbd54efdc3a5" xlink:href="abbv-20221231.xsd#abbv_LeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abbv_LeaseLiabilityPaymentsDue_a2ecab88-0444-4c54-b97b-ab96ae2101a2" xlink:to="loc_abbv_LeaseLiabilityPaymentsDueYearTwo_3dbf3754-f23c-4082-b1ab-cbd54efdc3a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LeaseLiabilityPaymentsDueYearThree_14c89f8b-7311-48eb-9836-5a09cf0a4be4" xlink:href="abbv-20221231.xsd#abbv_LeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abbv_LeaseLiabilityPaymentsDue_a2ecab88-0444-4c54-b97b-ab96ae2101a2" xlink:to="loc_abbv_LeaseLiabilityPaymentsDueYearThree_14c89f8b-7311-48eb-9836-5a09cf0a4be4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LeaseLiabilityPaymentsDueYearFour_1dfb2c6d-2be7-4325-b007-289abb822def" xlink:href="abbv-20221231.xsd#abbv_LeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abbv_LeaseLiabilityPaymentsDue_a2ecab88-0444-4c54-b97b-ab96ae2101a2" xlink:to="loc_abbv_LeaseLiabilityPaymentsDueYearFour_1dfb2c6d-2be7-4325-b007-289abb822def" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LeaseLiabilityPaymentsDueafterYearFive_f4c6f196-9b78-4af5-a399-d61276799f80" xlink:href="abbv-20221231.xsd#abbv_LeaseLiabilityPaymentsDueafterYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abbv_LeaseLiabilityPaymentsDue_a2ecab88-0444-4c54-b97b-ab96ae2101a2" xlink:to="loc_abbv_LeaseLiabilityPaymentsDueafterYearFive_f4c6f196-9b78-4af5-a399-d61276799f80" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LeaseLiabilityPaymentsDueYearFive_230dd2ed-6ddd-4570-97d0-91598156030e" xlink:href="abbv-20221231.xsd#abbv_LeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abbv_LeaseLiabilityPaymentsDue_a2ecab88-0444-4c54-b97b-ab96ae2101a2" xlink:to="loc_abbv_LeaseLiabilityPaymentsDueYearFive_230dd2ed-6ddd-4570-97d0-91598156030e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_85407fa3-e036-4525-bd8d-70864ac7142b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_fee0704e-0563-4a48-ba1f-ad01c3119fe0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_85407fa3-e036-4525-bd8d-70864ac7142b" xlink:to="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_fee0704e-0563-4a48-ba1f-ad01c3119fe0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_3d511561-c3c7-4b4e-aaea-b63515c93af4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_85407fa3-e036-4525-bd8d-70864ac7142b" xlink:to="loc_us-gaap_FinanceLeaseLiability_3d511561-c3c7-4b4e-aaea-b63515c93af4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/DebtCreditFacilitiesandCommitmentsandContingenciesSummaryofLongTermDebtDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#DebtCreditFacilitiesandCommitmentsandContingenciesSummaryofLongTermDebtDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/DebtCreditFacilitiesandCommitmentsandContingenciesSummaryofLongTermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtAndCapitalLeaseObligations_89d6a545-1ab4-4dc8-90bd-19378a7c7310" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtAndCapitalLeaseObligations"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LongTermDebtAndCapitalLeaseObligationsGross_0206797f-e7d9-465b-8eb1-f382e3f53acb" xlink:href="abbv-20221231.xsd#abbv_LongTermDebtAndCapitalLeaseObligationsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtAndCapitalLeaseObligations_89d6a545-1ab4-4dc8-90bd-19378a7c7310" xlink:to="loc_abbv_LongTermDebtAndCapitalLeaseObligationsGross_0206797f-e7d9-465b-8eb1-f382e3f53acb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LongTermDebtAndCapitalLeaseObligationsDebtInstrumentUnamortizedDiscounts_f3e66334-da5c-4ff5-a44a-1835f24b372e" xlink:href="abbv-20221231.xsd#abbv_LongTermDebtAndCapitalLeaseObligationsDebtInstrumentUnamortizedDiscounts"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtAndCapitalLeaseObligations_89d6a545-1ab4-4dc8-90bd-19378a7c7310" xlink:to="loc_abbv_LongTermDebtAndCapitalLeaseObligationsDebtInstrumentUnamortizedDiscounts_f3e66334-da5c-4ff5-a44a-1835f24b372e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LongTermDebtAndCapitalLeaseObligationsDebtInstrumentUnamortizedFinancingCosts_51c3b875-8d42-4c68-b650-18df20b7a760" xlink:href="abbv-20221231.xsd#abbv_LongTermDebtAndCapitalLeaseObligationsDebtInstrumentUnamortizedFinancingCosts"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtAndCapitalLeaseObligations_89d6a545-1ab4-4dc8-90bd-19378a7c7310" xlink:to="loc_abbv_LongTermDebtAndCapitalLeaseObligationsDebtInstrumentUnamortizedFinancingCosts_51c3b875-8d42-4c68-b650-18df20b7a760" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LongTermDebtAndFinanceLeaseObligationsDebtInstrumentUnamortizedPremiums_750dfec4-ab27-45ab-a50c-9dec0fb2c05c" xlink:href="abbv-20221231.xsd#abbv_LongTermDebtAndFinanceLeaseObligationsDebtInstrumentUnamortizedPremiums"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtAndCapitalLeaseObligations_89d6a545-1ab4-4dc8-90bd-19378a7c7310" xlink:to="loc_abbv_LongTermDebtAndFinanceLeaseObligationsDebtInstrumentUnamortizedPremiums_750dfec4-ab27-45ab-a50c-9dec0fb2c05c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LongTermDebtAndCapitalLeaseObligationsFairValueHedgesNet_5354d0d0-4ff5-4be0-822a-afff692cea97" xlink:href="abbv-20221231.xsd#abbv_LongTermDebtAndCapitalLeaseObligationsFairValueHedgesNet"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtAndCapitalLeaseObligations_89d6a545-1ab4-4dc8-90bd-19378a7c7310" xlink:to="loc_abbv_LongTermDebtAndCapitalLeaseObligationsFairValueHedgesNet_5354d0d0-4ff5-4be0-822a-afff692cea97" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/DebtCreditFacilitiesandCommitmentsandContingenciesSummaryofLongTermDebtDetails_1" xlink:type="simple" xlink:href="abbv-20221231.xsd#DebtCreditFacilitiesandCommitmentsandContingenciesSummaryofLongTermDebtDetails_1"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/DebtCreditFacilitiesandCommitmentsandContingenciesSummaryofLongTermDebtDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtAndCapitalLeaseObligations_3c20099e-d826-4254-88a1-b41cd2e786b1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtAndCapitalLeaseObligations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent_fc20e965-c4b5-4fc2-90a3-43ebf96d66ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtAndCapitalLeaseObligations_3c20099e-d826-4254-88a1-b41cd2e786b1" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent_fc20e965-c4b5-4fc2-90a3-43ebf96d66ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_1f476a7e-fcff-40e6-8008-513f178eeb08" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligations"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtAndCapitalLeaseObligations_3c20099e-d826-4254-88a1-b41cd2e786b1" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_1f476a7e-fcff-40e6-8008-513f178eeb08" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/FinancialInstrumentsandFairValueMeasuresFairValueMeasuresDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#FinancialInstrumentsandFairValueMeasuresFairValueMeasuresDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/FinancialInstrumentsandFairValueMeasuresFairValueMeasuresDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_c82f3cc9-c744-4efa-aca4-87940a0a6cde" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateDerivativeLiabilitiesAtFairValue_45b24f35-8fbb-4c8e-9e66-438153c6e5d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateDerivativeLiabilitiesAtFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_c82f3cc9-c744-4efa-aca4-87940a0a6cde" xlink:to="loc_us-gaap_InterestRateDerivativeLiabilitiesAtFairValue_45b24f35-8fbb-4c8e-9e66-438153c6e5d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_379f8aef-723d-417b-b9e2-1a207b5c1c73" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_c82f3cc9-c744-4efa-aca4-87940a0a6cde" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_379f8aef-723d-417b-b9e2-1a207b5c1c73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_9c6ccead-efd0-47f6-8b7e-1fa16225ab8a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_c82f3cc9-c744-4efa-aca4-87940a0a6cde" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_9c6ccead-efd0-47f6-8b7e-1fa16225ab8a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_40affe6a-9cb8-46a3-8a17-6b2b5b92bcfb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_677e4047-7070-48aa-896b-b800d2c93ff0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_40affe6a-9cb8-46a3-8a17-6b2b5b92bcfb" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_677e4047-7070-48aa-896b-b800d2c93ff0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent_0e467118-5b99-4b5c-a516-f50e61b09f2b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_40affe6a-9cb8-46a3-8a17-6b2b5b92bcfb" xlink:to="loc_us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent_0e467118-5b99-4b5c-a516-f50e61b09f2b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_c2dfa2e6-4934-4b52-995f-b078e2058d0c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_40affe6a-9cb8-46a3-8a17-6b2b5b92bcfb" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_c2dfa2e6-4934-4b52-995f-b078e2058d0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateDerivativeAssetsAtFairValue_63e80a82-9746-46ee-8f79-b557f864ea11" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateDerivativeAssetsAtFairValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_40affe6a-9cb8-46a3-8a17-6b2b5b92bcfb" xlink:to="loc_us-gaap_InterestRateDerivativeAssetsAtFairValue_63e80a82-9746-46ee-8f79-b557f864ea11" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_1e73bf7b-a011-4a8f-9caa-edcbc1dba63c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_40affe6a-9cb8-46a3-8a17-6b2b5b92bcfb" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_1e73bf7b-a011-4a8f-9caa-edcbc1dba63c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateDerivativeAssetsAtFairValue_f1560ea2-c12a-438b-9e2f-49d44509248b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateDerivativeAssetsAtFairValue"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_40affe6a-9cb8-46a3-8a17-6b2b5b92bcfb" xlink:to="loc_us-gaap_InterestRateDerivativeAssetsAtFairValue_f1560ea2-c12a-438b-9e2f-49d44509248b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4b3f697b-e2c1-4476-817c-70e3b21c6dbd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_40affe6a-9cb8-46a3-8a17-6b2b5b92bcfb" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4b3f697b-e2c1-4476-817c-70e3b21c6dbd" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/FinancialInstrumentsandFairValueMeasuresBasesUsedtoMeasureTheApproximateFairValueofFinancialInstrumentsDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#FinancialInstrumentsandFairValueMeasuresBasesUsedtoMeasureTheApproximateFairValueofFinancialInstrumentsDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/FinancialInstrumentsandFairValueMeasuresBasesUsedtoMeasureTheApproximateFairValueofFinancialInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_b2adf6d3-beda-491e-8de3-e45d74440b1c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShorttermDebtFairValue_2ef29d98-3bf9-4a13-8eaf-7cd220aa3e39" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShorttermDebtFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_b2adf6d3-beda-491e-8de3-e45d74440b1c" xlink:to="loc_us-gaap_ShorttermDebtFairValue_2ef29d98-3bf9-4a13-8eaf-7cd220aa3e39" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LongTermDebtAndCapitalLeaseObligationsCurrentFairValueDisclosure_6359cd2e-2d27-471f-b9c7-a495928a004b" xlink:href="abbv-20221231.xsd#abbv_LongTermDebtAndCapitalLeaseObligationsCurrentFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_b2adf6d3-beda-491e-8de3-e45d74440b1c" xlink:to="loc_abbv_LongTermDebtAndCapitalLeaseObligationsCurrentFairValueDisclosure_6359cd2e-2d27-471f-b9c7-a495928a004b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_LongTermDebtAndCapitalLeaseObligationsFairValueDisclosure_2c0f03bb-eb2c-4c90-bbea-9d59a4913fa6" xlink:href="abbv-20221231.xsd#abbv_LongTermDebtAndCapitalLeaseObligationsFairValueDisclosure"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_b2adf6d3-beda-491e-8de3-e45d74440b1c" xlink:to="loc_abbv_LongTermDebtAndCapitalLeaseObligationsFairValueDisclosure_2c0f03bb-eb2c-4c90-bbea-9d59a4913fa6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/PostEmploymentBenefitsBenefitPlanInformationDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#PostEmploymentBenefitsBenefitPlanInformationDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/PostEmploymentBenefitsBenefitPlanInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet_83a74131-2e07-4087-af81-234697e7b510" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansCurrentLiabilities_829f6bec-c83d-4de8-a646-ac51d9afab72" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansCurrentLiabilities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet_83a74131-2e07-4087-af81-234697e7b510" xlink:to="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansCurrentLiabilities_829f6bec-c83d-4de8-a646-ac51d9afab72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_c78a01c1-bbb3-4b30-a78b-8f531008a2a0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet_83a74131-2e07-4087-af81-234697e7b510" xlink:to="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_c78a01c1-bbb3-4b30-a78b-8f531008a2a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent_42a11d9a-98fa-4433-8bc5-589baa80a0fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet_83a74131-2e07-4087-af81-234697e7b510" xlink:to="loc_us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent_42a11d9a-98fa-4433-8bc5-589baa80a0fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanFundedStatusOfPlan_b2836d19-72b3-4189-85ce-54b320816937" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanFundedStatusOfPlan"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanBenefitObligation_b3866d52-961a-48a6-b4c9-47a203d1eb1f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanBenefitObligation"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanFundedStatusOfPlan_b2836d19-72b3-4189-85ce-54b320816937" xlink:to="loc_us-gaap_DefinedBenefitPlanBenefitObligation_b3866d52-961a-48a6-b4c9-47a203d1eb1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_512550f8-4452-4c0d-bfe9-a5b9aee19c5f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanFairValueOfPlanAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanFundedStatusOfPlan_b2836d19-72b3-4189-85ce-54b320816937" xlink:to="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_512550f8-4452-4c0d-bfe9-a5b9aee19c5f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_71c8ad9b-9f26-4df9-bf2b-fc8a1f13f12c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax_2d7a12a7-26d4-4cf7-a28e-8ad09df25979" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_71c8ad9b-9f26-4df9-bf2b-fc8a1f13f12c" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax_2d7a12a7-26d4-4cf7-a28e-8ad09df25979" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_61e0a38e-f99e-4e12-80f1-2b39afbfa19d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_71c8ad9b-9f26-4df9-bf2b-fc8a1f13f12c" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_61e0a38e-f99e-4e12-80f1-2b39afbfa19d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/PostEmploymentBenefitsPretaxGainsandLossesIncludedinOtherComprehensiveIncomeLossDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#PostEmploymentBenefitsPretaxGainsandLossesIncludedinOtherComprehensiveIncomeLossDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/PostEmploymentBenefitsPretaxGainsandLossesIncludedinOtherComprehensiveIncomeLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_2a5e7aa8-28ac-47cc-88c1-c5e2e5cb732f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax_3bc83012-7978-42d5-9ac4-fefad77b46fe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_2a5e7aa8-28ac-47cc-88c1-c5e2e5cb732f" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax_3bc83012-7978-42d5-9ac4-fefad77b46fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_f7de6f80-620f-4538-90c3-33cf92d0b1c2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_2a5e7aa8-28ac-47cc-88c1-c5e2e5cb732f" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_f7de6f80-620f-4538-90c3-33cf92d0b1c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax_34791f95-e35b-4de5-be36-5b9864fe2645" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_2a5e7aa8-28ac-47cc-88c1-c5e2e5cb732f" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax_34791f95-e35b-4de5-be36-5b9864fe2645" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeLossForeignExchangeGainLossAndOtherBeforeTax_b1ed0212-fa15-4236-ba0d-4e7156e23d0d" xlink:href="abbv-20221231.xsd#abbv_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeLossForeignExchangeGainLossAndOtherBeforeTax"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_2a5e7aa8-28ac-47cc-88c1-c5e2e5cb732f" xlink:to="loc_abbv_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeLossForeignExchangeGainLossAndOtherBeforeTax_b1ed0212-fa15-4236-ba0d-4e7156e23d0d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlanNetPriorServiceCostCreditArisingDuringPeriodBeforeTax_d44f0e2a-e6b1-4ac9-973f-54ea66c16f0d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeDefinedBenefitPlanNetPriorServiceCostCreditArisingDuringPeriodBeforeTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_2a5e7aa8-28ac-47cc-88c1-c5e2e5cb732f" xlink:to="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlanNetPriorServiceCostCreditArisingDuringPeriodBeforeTax_d44f0e2a-e6b1-4ac9-973f-54ea66c16f0d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/PostEmploymentBenefitsNetPeriodicBenefitCostDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#PostEmploymentBenefitsNetPeriodicBenefitCostDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/PostEmploymentBenefitsNetPeriodicBenefitCostDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_bae016ea-520b-47b2-b07a-8c1c6141f934" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_aec40816-203f-4220-b9d5-50f158f9df5e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanServiceCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_bae016ea-520b-47b2-b07a-8c1c6141f934" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_aec40816-203f-4220-b9d5-50f158f9df5e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_20ef8cc8-a788-4f09-b87d-55dd8f484c15" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_bae016ea-520b-47b2-b07a-8c1c6141f934" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_20ef8cc8-a788-4f09-b87d-55dd8f484c15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_ffba5308-28d5-444f-9109-5b923c39ab0a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_bae016ea-520b-47b2-b07a-8c1c6141f934" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_ffba5308-28d5-444f-9109-5b923c39ab0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_f9a1d159-bd3c-4b25-8319-511e4d188456" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_bae016ea-520b-47b2-b07a-8c1c6141f934" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_f9a1d159-bd3c-4b25-8319-511e4d188456" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_04d0c4d4-d3de-4786-9dec-0e1bdee731a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_bae016ea-520b-47b2-b07a-8c1c6141f934" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_04d0c4d4-d3de-4786-9dec-0e1bdee731a7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/EquityStockBasedCompensationDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#EquityStockBasedCompensationDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/EquityStockBasedCompensationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_1022c48e-c266-43a1-901c-24d7b1da0631" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_0596084d-368f-4967-8028-571b74ecb25d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_1022c48e-c266-43a1-901c-24d7b1da0631" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_0596084d-368f-4967-8028-571b74ecb25d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_795c70c0-0955-4b60-afc5-ff2f1dc1394d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_1022c48e-c266-43a1-901c-24d7b1da0631" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_795c70c0-0955-4b60-afc5-ff2f1dc1394d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/EquityAccumulatedOtherComprehensiveLossDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#EquityAccumulatedOtherComprehensiveLossDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/EquityAccumulatedOtherComprehensiveLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_df3c37d4-b62b-443b-b9f6-d36679cdba58" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_870bda6e-690c-4daf-ab34-e5604dce1b1b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_df3c37d4-b62b-443b-b9f6-d36679cdba58" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_870bda6e-690c-4daf-ab34-e5604dce1b1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_0b3d7a98-32da-4da2-a356-54513ee0df19" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_df3c37d4-b62b-443b-b9f6-d36679cdba58" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_0b3d7a98-32da-4da2-a356-54513ee0df19" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/EquityAmountsReclassifiedOutOfAccumulatedOtherComprehensiveLossDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#EquityAmountsReclassifiedOutOfAccumulatedOtherComprehensiveLossDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/EquityAmountsReclassifiedOutOfAccumulatedOtherComprehensiveLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_625f7121-fcc2-4fe2-b75f-0bb99286897b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_92736f89-9c93-4b58-97a3-46f72b62e45f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_625f7121-fcc2-4fe2-b75f-0bb99286897b" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_92736f89-9c93-4b58-97a3-46f72b62e45f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_51cf9086-8ae6-4ccd-9cc8-580041329934" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_625f7121-fcc2-4fe2-b75f-0bb99286897b" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_51cf9086-8ae6-4ccd-9cc8-580041329934" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_5b3147f1-b083-40f4-9cc6-3f8e26f72063" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_625f7121-fcc2-4fe2-b75f-0bb99286897b" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_5b3147f1-b083-40f4-9cc6-3f8e26f72063" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_0f8bdaab-9493-48f6-81c4-721cd78cf59e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax_44cdcfee-3488-4e81-986e-1d595b447d4d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_0f8bdaab-9493-48f6-81c4-721cd78cf59e" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax_44cdcfee-3488-4e81-986e-1d595b447d4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAociCurrentPeriodTax_a25ff307-07fd-41db-941c-c51a36f0dea5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReclassificationFromAociCurrentPeriodTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_0f8bdaab-9493-48f6-81c4-721cd78cf59e" xlink:to="loc_us-gaap_ReclassificationFromAociCurrentPeriodTax_a25ff307-07fd-41db-941c-c51a36f0dea5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/IncomeTaxesEarningsBeforeIncomeTaxExpenseDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#IncomeTaxesEarningsBeforeIncomeTaxExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/IncomeTaxesEarningsBeforeIncomeTaxExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_48006d43-9f4d-4fb7-a323-d4e1304f259a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_44b065a2-4722-4f37-9322-893b16ea5bd3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_48006d43-9f4d-4fb7-a323-d4e1304f259a" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_44b065a2-4722-4f37-9322-893b16ea5bd3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_1679c789-c1a9-48be-8a22-c21a69b08383" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_48006d43-9f4d-4fb7-a323-d4e1304f259a" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_1679c789-c1a9-48be-8a22-c21a69b08383" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/IncomeTaxesIncomeTaxExpenseDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#IncomeTaxesIncomeTaxExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/IncomeTaxesIncomeTaxExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_6b0759dd-e835-4d3f-b393-12057d53f00b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_f59a82cf-ce38-46f5-b168-a42f6f24fa72" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_6b0759dd-e835-4d3f-b393-12057d53f00b" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_f59a82cf-ce38-46f5-b168-a42f6f24fa72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_8f1800ed-6f91-40ab-a952-abffcb443fda" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_6b0759dd-e835-4d3f-b393-12057d53f00b" xlink:to="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_8f1800ed-6f91-40ab-a952-abffcb443fda" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_0bc70dd4-e42c-4362-9259-3d2ad9ab2378" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_fd7fc07a-3d35-4c11-9ef3-1e23d73fede8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CurrentFederalTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_0bc70dd4-e42c-4362-9259-3d2ad9ab2378" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_fd7fc07a-3d35-4c11-9ef3-1e23d73fede8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentForeignTaxExpenseBenefit_3274d2bb-6787-43b7-bbce-c2ef6db1ed1a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CurrentForeignTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_0bc70dd4-e42c-4362-9259-3d2ad9ab2378" xlink:to="loc_us-gaap_CurrentForeignTaxExpenseBenefit_3274d2bb-6787-43b7-bbce-c2ef6db1ed1a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_09f676cb-07f6-4d9f-b634-6555c3a2ce20" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_73a83162-e667-48ba-96c6-585fa6407a5f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_09f676cb-07f6-4d9f-b634-6555c3a2ce20" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_73a83162-e667-48ba-96c6-585fa6407a5f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_3e6d36fe-a054-4ea4-a265-4f87dd0f2a36" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_09f676cb-07f6-4d9f-b634-6555c3a2ce20" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_3e6d36fe-a054-4ea4-a265-4f87dd0f2a36" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/IncomeTaxesEffectiveTaxRateReconciliationDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#IncomeTaxesEffectiveTaxRateReconciliationDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/IncomeTaxesEffectiveTaxRateReconciliationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_796a8c44-0431-4180-a3c2-f01c60522751" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_bae0a6f0-4e32-48b5-a7d5-459864b52d22" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_796a8c44-0431-4180-a3c2-f01c60522751" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_bae0a6f0-4e32-48b5-a7d5-459864b52d22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_1504d71b-d3a5-499e-867e-b0f62980202e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_796a8c44-0431-4180-a3c2-f01c60522751" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_1504d71b-d3a5-499e-867e-b0f62980202e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_EffectiveIncomeTaxRateReconciliationUsTaxCredits_0020911c-cfa4-41b2-b390-0a14d8e73ba2" xlink:href="abbv-20221231.xsd#abbv_EffectiveIncomeTaxRateReconciliationUsTaxCredits"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_796a8c44-0431-4180-a3c2-f01c60522751" xlink:to="loc_abbv_EffectiveIncomeTaxRateReconciliationUsTaxCredits_0020911c-cfa4-41b2-b390-0a14d8e73ba2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_EffectiveIncomeTaxRateReconciliationImpactsRelatedtoU.S.TaxReform_44efa968-28be-44b6-9061-baea09ee7694" xlink:href="abbv-20221231.xsd#abbv_EffectiveIncomeTaxRateReconciliationImpactsRelatedtoU.S.TaxReform"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_796a8c44-0431-4180-a3c2-f01c60522751" xlink:to="loc_abbv_EffectiveIncomeTaxRateReconciliationImpactsRelatedtoU.S.TaxReform_44efa968-28be-44b6-9061-baea09ee7694" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_5b85051b-e02c-4b16-b096-7c861ad6bf34" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_796a8c44-0431-4180-a3c2-f01c60522751" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_5b85051b-e02c-4b16-b096-7c861ad6bf34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxSettlements_70dd1b82-322e-44cc-af81-17f70c6b7cf4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxSettlements"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_796a8c44-0431-4180-a3c2-f01c60522751" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxSettlements_70dd1b82-322e-44cc-af81-17f70c6b7cf4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpense_2712e36a-40b1-444c-b1b8-639c23af1757" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpense"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_796a8c44-0431-4180-a3c2-f01c60522751" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpense_2712e36a-40b1-444c-b1b8-639c23af1757" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_EffectiveIncomeTaxRateReconciliationTaxLawChangesAndRelatedRestructuringPercent_7e0162f4-03cc-4954-b72a-0ad0110a6814" xlink:href="abbv-20221231.xsd#abbv_EffectiveIncomeTaxRateReconciliationTaxLawChangesAndRelatedRestructuringPercent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_796a8c44-0431-4180-a3c2-f01c60522751" xlink:to="loc_abbv_EffectiveIncomeTaxRateReconciliationTaxLawChangesAndRelatedRestructuringPercent_7e0162f4-03cc-4954-b72a-0ad0110a6814" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.abbvie.com/role/IncomeTaxesDeferredTaxAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="abbv-20221231.xsd#IncomeTaxesDeferredTaxAssetsandLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.abbvie.com/role/IncomeTaxesDeferredTaxAssetsandLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_abbv_NetDeferredTaxAssetsLiabilities_9ba2f407-0c46-4ccc-9ba5-13e6d50fa7ec" xlink:href="abbv-20221231.xsd#abbv_NetDeferredTaxAssetsLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_9555e0a8-09dd-4c45-9c80-7870ece2a06d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abbv_NetDeferredTaxAssetsLiabilities_9ba2f407-0c46-4ccc-9ba5-13e6d50fa7ec" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_9555e0a8-09dd-4c45-9c80-7870ece2a06d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_9948fbc9-8c2f-43ee-b7b7-31a5f2a0fc43" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_abbv_NetDeferredTaxAssetsLiabilities_9ba2f407-0c46-4ccc-9ba5-13e6d50fa7ec" xlink:to="loc_us-gaap_DeferredTaxAssetsNet_9948fbc9-8c2f-43ee-b7b7-31a5f2a0fc43" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_081b5b90-d5f6-4649-9638-3e15948c04c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_634abd3c-d845-41ec-95d1-2893e55b90c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_081b5b90-d5f6-4649-9638-3e15948c04c7" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_634abd3c-d845-41ec-95d1-2893e55b90c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesInvestments_6ef9ec45-6f35-425f-a182-6bbfeb59347f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxLiabilitiesInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_081b5b90-d5f6-4649-9638-3e15948c04c7" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesInvestments_6ef9ec45-6f35-425f-a182-6bbfeb59347f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesOther_d233d377-46ca-46c8-baee-f0dd50a62476" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxLiabilitiesOther"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_081b5b90-d5f6-4649-9638-3e15948c04c7" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesOther_d233d377-46ca-46c8-baee-f0dd50a62476" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_14d0d819-4869-44a7-b538-95a092bf0aa6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits_acedb288-2f02-4849-b440-8ef130b98347" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_14d0d819-4869-44a7-b538-95a092bf0aa6" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits_acedb288-2f02-4849-b440-8ef130b98347" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals_22438df2-2e42-4d25-9d49-d12b9b735458" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_14d0d819-4869-44a7-b538-95a092bf0aa6" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals_22438df2-2e42-4d25-9d49-d12b9b735458" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_DeferredTaxAssetsChargebacksAndRebates_0333b992-0e3d-4c56-a387-3925febc9210" xlink:href="abbv-20221231.xsd#abbv_DeferredTaxAssetsChargebacksAndRebates"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_14d0d819-4869-44a7-b538-95a092bf0aa6" xlink:to="loc_abbv_DeferredTaxAssetsChargebacksAndRebates_0333b992-0e3d-4c56-a387-3925febc9210" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsDeferredIncome_87f2dcc1-c94c-49c4-8aae-accc5878460e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsDeferredIncome"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_14d0d819-4869-44a7-b538-95a092bf0aa6" xlink:to="loc_us-gaap_DeferredTaxAssetsDeferredIncome_87f2dcc1-c94c-49c4-8aae-accc5878460e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_DeferredTaxAssetsOperatingLossAndOtherTaxCreditCarryforwards_376f87e7-129e-47f9-95e4-cda3a6ec9f86" xlink:href="abbv-20221231.xsd#abbv_DeferredTaxAssetsOperatingLossAndOtherTaxCreditCarryforwards"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_14d0d819-4869-44a7-b538-95a092bf0aa6" xlink:to="loc_abbv_DeferredTaxAssetsOperatingLossAndOtherTaxCreditCarryforwards_376f87e7-129e-47f9-95e4-cda3a6ec9f86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_6d9c9530-2e43-4fe7-8ee3-7b787afaca90" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_14d0d819-4869-44a7-b538-95a092bf0aa6" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_6d9c9530-2e43-4fe7-8ee3-7b787afaca90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_1516f98a-2005-4030-8cfb-b0978fa393d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_88a12e07-4f7f-4556-a72a-5d78e39e6b45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_1516f98a-2005-4030-8cfb-b0978fa393d1" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_88a12e07-4f7f-4556-a72a-5d78e39e6b45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_fa78f7d3-3676-432f-88db-f1d791daf17b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_1516f98a-2005-4030-8cfb-b0978fa393d1" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_fa78f7d3-3676-432f-88db-f1d791daf17b" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
