<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:5d7c0ab2-39a4-4699-a21e-1f3ee85e58ab,g:a8110eba-2390-48c0-bca0-cd57dd25cb82-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.abbvie.com/role/DocumentandEntityInformationDocument" xlink:type="simple" xlink:href="abbv-20221028.xsd#DocumentandEntityInformationDocument"/>
  <link:definitionLink xlink:role="http://www.abbvie.com/role/DocumentandEntityInformationDocument" xlink:type="extended" id="i105b09eead77492a92a57defd4403f89_DocumentandEntityInformationDocument">
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_911db16b-bf20-495c-9eec-93f03f5dc566" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_DocumentType_911db16b-bf20-495c-9eec-93f03f5dc566" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_971a256d-21a3-4377-a389-42b6e17e5f2e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_DocumentPeriodEndDate_971a256d-21a3-4377-a389-42b6e17e5f2e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_a960df5b-6a53-4a38-b8ab-cf2c53b19680" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_EntityRegistrantName_a960df5b-6a53-4a38-b8ab-cf2c53b19680" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_904371f6-58cd-4d4a-80c1-e7dcb6afbe0c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_EntityCentralIndexKey_904371f6-58cd-4d4a-80c1-e7dcb6afbe0c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_8b9896c2-fff9-4437-a2ae-7dd9c703c900" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_AmendmentFlag_8b9896c2-fff9-4437-a2ae-7dd9c703c900" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_5f6186a4-40a7-4eed-ae63-31d799627c3e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_EntityIncorporationStateCountryCode_5f6186a4-40a7-4eed-ae63-31d799627c3e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_bef801d2-0153-435c-b364-5631961f3796" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_EntityFileNumber_bef801d2-0153-435c-b364-5631961f3796" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_9815bc17-49d5-4c65-8ae4-6b1e1f5805d8" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_EntityTaxIdentificationNumber_9815bc17-49d5-4c65-8ae4-6b1e1f5805d8" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_09fbed73-7926-4391-a142-2df236719499" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_EntityAddressAddressLine1_09fbed73-7926-4391-a142-2df236719499" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_e6467896-4fc1-43b0-a418-ecd52e64e4f6" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_EntityAddressCityOrTown_e6467896-4fc1-43b0-a418-ecd52e64e4f6" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_d5166d7d-35d2-4af7-837f-4eb8beb220c8" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressStateOrProvince"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_EntityAddressStateOrProvince_d5166d7d-35d2-4af7-837f-4eb8beb220c8" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_a72a0588-900a-4660-84c9-8992aca7e23a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_EntityAddressPostalZipCode_a72a0588-900a-4660-84c9-8992aca7e23a" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_0ccd4675-0051-4409-bb3d-e86174ce5df6" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_CityAreaCode_0ccd4675-0051-4409-bb3d-e86174ce5df6" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_67538ac0-4e63-4c07-9f2e-436ee94acd57" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_LocalPhoneNumber_67538ac0-4e63-4c07-9f2e-436ee94acd57" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_604942b4-3384-4c42-872e-cb33298474a2" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_WrittenCommunications"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_WrittenCommunications_604942b4-3384-4c42-872e-cb33298474a2" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_d5849180-56f7-4ab3-9b8a-f67963ff96ec" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SolicitingMaterial"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_SolicitingMaterial_d5849180-56f7-4ab3-9b8a-f67963ff96ec" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_ba50193f-3477-47d7-abf4-824ca44b4f94" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementTenderOffer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_PreCommencementTenderOffer_ba50193f-3477-47d7-abf4-824ca44b4f94" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_e2954dfe-418e-408e-b208-c77cf72902c4" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_e2954dfe-418e-408e-b208-c77cf72902c4" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_c72b58db-1f5e-472d-8e69-ab2d3c7d8151" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_Security12bTitle_c72b58db-1f5e-472d-8e69-ab2d3c7d8151" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_562bc2d5-7387-40f4-8830-157bcedba239" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_TradingSymbol_562bc2d5-7387-40f4-8830-157bcedba239" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_db8c94b1-7a47-44d2-964d-d3493808f854" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_SecurityExchangeName_db8c94b1-7a47-44d2-964d-d3493808f854" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_68c39ce9-00b3-4438-a17d-e4418cf6cb1f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_EntityEmergingGrowthCompany_68c39ce9-00b3-4438-a17d-e4418cf6cb1f" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_a54250a9-2c0c-437e-af8e-402207c3d8bf" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_EntityInformationLineItems_873e04d0-73b1-4c1f-ba2a-8555a575799f" xlink:to="loc_dei_EntitiesTable_a54250a9-2c0c-437e-af8e-402207c3d8bf" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_83c19fc9-34d4-4e9a-b87d-52d4671034c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_EntitiesTable_a54250a9-2c0c-437e-af8e-402207c3d8bf" xlink:to="loc_us-gaap_StatementClassOfStockAxis_83c19fc9-34d4-4e9a-b87d-52d4671034c7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_83c19fc9-34d4-4e9a-b87d-52d4671034c7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_83c19fc9-34d4-4e9a-b87d-52d4671034c7" xlink:to="loc_us-gaap_ClassOfStockDomain_83c19fc9-34d4-4e9a-b87d-52d4671034c7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_4f2374e7-e63c-4c1a-81bf-ca6862c8efd3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_83c19fc9-34d4-4e9a-b87d-52d4671034c7" xlink:to="loc_us-gaap_ClassOfStockDomain_4f2374e7-e63c-4c1a-81bf-ca6862c8efd3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_56e6829a-4dae-4f2c-adeb-7f65dfc6fc1e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_4f2374e7-e63c-4c1a-81bf-ca6862c8efd3" xlink:to="loc_us-gaap_CommonStockMember_56e6829a-4dae-4f2c-adeb-7f65dfc6fc1e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_Sec1500SeniorNotesDue2023Member_bcbab8db-9dc9-4c9e-a1a8-3757e4ca8c9c" xlink:href="abbv-20221028.xsd#abbv_Sec1500SeniorNotesDue2023Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_4f2374e7-e63c-4c1a-81bf-ca6862c8efd3" xlink:to="loc_abbv_Sec1500SeniorNotesDue2023Member_bcbab8db-9dc9-4c9e-a1a8-3757e4ca8c9c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_Sec1.375SeniorNotesDue2024Member_5f2b6582-c9ef-4d3f-bb53-c34670d99699" xlink:href="abbv-20221028.xsd#abbv_Sec1.375SeniorNotesDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_4f2374e7-e63c-4c1a-81bf-ca6862c8efd3" xlink:to="loc_abbv_Sec1.375SeniorNotesDue2024Member_5f2b6582-c9ef-4d3f-bb53-c34670d99699" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_Sec1250SeniorNotesDue2024Member_909e32a1-dc90-417d-81e0-89d7435331b5" xlink:href="abbv-20221028.xsd#abbv_Sec1250SeniorNotesDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_4f2374e7-e63c-4c1a-81bf-ca6862c8efd3" xlink:to="loc_abbv_Sec1250SeniorNotesDue2024Member_909e32a1-dc90-417d-81e0-89d7435331b5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_Sec0.750SeniorNotesDue2027Member_f88996a8-60fd-482a-b52a-9b9289abaa36" xlink:href="abbv-20221028.xsd#abbv_Sec0.750SeniorNotesDue2027Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_4f2374e7-e63c-4c1a-81bf-ca6862c8efd3" xlink:to="loc_abbv_Sec0.750SeniorNotesDue2027Member_f88996a8-60fd-482a-b52a-9b9289abaa36" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_Sec2.125SeniorNotesdue2028Member_31b5ea7e-9dbf-4681-a410-07ffc6d30237" xlink:href="abbv-20221028.xsd#abbv_Sec2.125SeniorNotesdue2028Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_4f2374e7-e63c-4c1a-81bf-ca6862c8efd3" xlink:to="loc_abbv_Sec2.125SeniorNotesdue2028Member_31b5ea7e-9dbf-4681-a410-07ffc6d30237" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_Sec2625SeniorNotesDue2028Member_e6df2d56-4c58-4c46-8996-baef4eaab088" xlink:href="abbv-20221028.xsd#abbv_Sec2625SeniorNotesDue2028Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_4f2374e7-e63c-4c1a-81bf-ca6862c8efd3" xlink:to="loc_abbv_Sec2625SeniorNotesDue2028Member_e6df2d56-4c58-4c46-8996-baef4eaab088" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_Sec2125SeniorNotesDue2029Member_b6d82d70-809f-4a09-9e62-5567531dd2a5" xlink:href="abbv-20221028.xsd#abbv_Sec2125SeniorNotesDue2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_4f2374e7-e63c-4c1a-81bf-ca6862c8efd3" xlink:to="loc_abbv_Sec2125SeniorNotesDue2029Member_b6d82d70-809f-4a09-9e62-5567531dd2a5" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_abbv_Sec1.250SeniorNotesdue2031Member_c5275317-7c5d-4472-9983-21eee57ca62e" xlink:href="abbv-20221028.xsd#abbv_Sec1.250SeniorNotesdue2031Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_4f2374e7-e63c-4c1a-81bf-ca6862c8efd3" xlink:to="loc_abbv_Sec1.250SeniorNotesdue2031Member_c5275317-7c5d-4472-9983-21eee57ca62e" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityListingsExchangeAxis_f75d55a5-0958-404e-b821-7240ca560984" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityListingsExchangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_EntitiesTable_a54250a9-2c0c-437e-af8e-402207c3d8bf" xlink:to="loc_dei_EntityListingsExchangeAxis_f75d55a5-0958-404e-b821-7240ca560984" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_ExchangeDomain_f75d55a5-0958-404e-b821-7240ca560984_default" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_ExchangeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_EntityListingsExchangeAxis_f75d55a5-0958-404e-b821-7240ca560984" xlink:to="loc_dei_ExchangeDomain_f75d55a5-0958-404e-b821-7240ca560984_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_ExchangeDomain_3421bf3f-bf8b-48cf-a891-33d520a578cb" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_ExchangeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_EntityListingsExchangeAxis_f75d55a5-0958-404e-b821-7240ca560984" xlink:to="loc_dei_ExchangeDomain_3421bf3f-bf8b-48cf-a891-33d520a578cb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_exch_XNYS_127360b9-92d8-4619-9a39-256db7e8672b" xlink:href="https://xbrl.sec.gov/exch/2022/exch-2022.xsd#exch_XNYS"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_ExchangeDomain_3421bf3f-bf8b-48cf-a891-33d520a578cb" xlink:to="loc_exch_XNYS_127360b9-92d8-4619-9a39-256db7e8672b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_exch_XCHI_89428ea3-913d-4c9d-84e3-14490b910b84" xlink:href="https://xbrl.sec.gov/exch/2022/exch-2022.xsd#exch_XCHI"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_ExchangeDomain_3421bf3f-bf8b-48cf-a891-33d520a578cb" xlink:to="loc_exch_XCHI_89428ea3-913d-4c9d-84e3-14490b910b84" xlink:type="arc" order="1"/>
  </link:definitionLink>
</link:linkbase>
